ArticleScience signaling2011
Signaling by neuronal swelling.
Article in Science signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Synapses without tension fail to fire in an in vitro network of hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- All-optical observation on activity-dependent nanoscale dynamics of myelinated axons.Neurophotonics · 2023Article
- The role of the membrane-associated periodic skeleton in axons.Cellular and molecular life sciences : CMLS · 2021Review
- Rethinking the Conditions and Mechanism for Glymphatic Clearance.Frontiers in neuroscience · 2021Article
- Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Detection of cellular micromotion by advanced signal processing.Scientific reports · 2020Article
- Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment.Cells · 2020Review
- The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction.eLife · 2020Article
- Measurement and visualization of stimulus-evoked tissue dynamics in mouse barrel cortex using phase-sensitive optical coherence tomography.Biomedical optics express · 2020Article
- Action Potential: A Vortex Phenomena; Driving Membrane Oscillations.Frontiers in computational neuroscience · 2020Article
- On the sensitivity of the diffusion MRI signal to brain activity in response to a motor cortex paradigm.Human brain mapping · 2019Article
- Imaging localized neuronal activity at fast time scales through biomechanics.Science advances · 2019Article
- The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling.Frontiers in molecular neuroscience · 2018Review
- Superresolution imaging reveals activity-dependent plasticity of axon morphology linked to changes in action potential conduction velocity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Volume-regulated anion channel--a frenemy within the brain.Pflugers Archiv : European journal of physiology · 2016Review
- The genetic basis of natural variation in mushroom body size in Drosophila melanogaster.Nature communications · 2015Article
- The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization.PLoS computational biology · 2015Article
- Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.Molecular brain · 2015Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Several physical phenomena accompany the firing of electrical impulses by axons. Some of these, such as the microscopic swelling of axons, alter the transmission of light through axons. This produces what are called "intrinsic optical signals" because optical methods can be used to see axons fire without adding voltage-sensitive dyes or using electronic amplifiers. These physical changes allow neurons tocommunicate through nonsynaptic signals to adjacent cells, such as other neurons or glia. Two of the three videos in this Teaching Resource show the optical manifestations of the microscopic swelling of axons that accompanies the firing of action potentials in cultured neurons, and one shows the nonsynaptic release of ATP that occurs through membrane channels that are stimulated by neuronal swelling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.