ArticleScience signaling2011
Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling.
Article in Science signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 80 citations in OpenAlex.
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- Chemosensory tobacco product toxicology part 1: sensory mechanisms.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- Beyond the Surface: Investigating the Potential Mechanisms of Non-Motor Symptoms in Myasthenia Gravis.European journal of neurology · 2025Review
- Distinct odorant receptor response patterns to aliphatic odorants in freely behaving mice.Chemical senses · 2025Article
- Human Olfactory Receptor Sensor for Odor Reconstitution.Sensors (Basel, Switzerland) · 2023Review
- From musk to body odor: Decoding olfaction through genetic variation.PLoS genetics · 2022Article
- Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line.PloS one · 2022Article
- Machine Learning Assisted Approach for Finding Novel High Activity Agonists of Human Ectopic Olfactory Receptors.International journal of molecular sciences · 2021Article
- Modulation of olfactory signal detection in the olfactory epithelium: focus on the internal and external environment, and the emerging role of the immune system.Cell and tissue research · 2021Review
- The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking.The Journal of biological chemistry · 2019Article
- Mammalian class I odorant receptors exhibit a conserved vestibular-binding pocket.Cellular and molecular life sciences : CMLS · 2019Article
- Dynamical Binding Modes Determine Agonistic and Antagonistic Ligand Effects in the Prostate-Specific G-Protein Coupled Receptor (PSGR).Scientific reports · 2017Article
- Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay.Journal of visualized experiments : JoVE · 2017Article
- Modification of the response of olfactory receptors to acetophenone by CYP1a2.Scientific reports · 2017Article
- Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.eLife · 2017Article
- Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor.Basic research in cardiology · 2017Article
- Receptor-transporting protein (RTP) family members play divergent roles in the functional expression of odorant receptors.PloS one · 2017Article
- Deep Sequencing of the Human Retinae Reveals the Expression of Odorant Receptors.Frontiers in cellular neuroscience · 2017Article
- Mammalian odorant receptors: functional evolution and variation.Current opinion in neurobiology · 2015Review
- Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo.Nature neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A diverse repertoire of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) enables cells to sense their environment. Mammalian olfaction requires the activation of odorant receptors (ORs), the largest family of GPCRs; however, whether ORs functionally interact with other families of GPCRs is unclear. We show that the interaction of ORs with the type 3 muscarinic acetylcholine receptor (M3-R), which is found in olfactory sensory neurons (OSNs), modulated OR responses to cognate odorants. In human embryonic kidney-293T cells, ORs and the M3-R physically interacted, and the M3-R increased the potency and efficacy of odorant-elicited responses of several ORs. Selective M3-R antagonists attenuated odorant-dependent activation of OSNs, and, when the M3-R and ORs were expressed in transfected cells, OR activation was enhanced by muscarinic agonists and inhibited by muscarinic antagonists. Furthermore, M3-R-dependent potentiation of OR signaling synergized with that of receptor transporting protein 1S (RTP1S), an accessory factor required for the efficient membrane targeting of ORs. However, the M3-R did not enhance the abundance of ORs at the cell surface, suggesting that the M3-R acted through a distinct mechanism independent of RTP1S. Finally, the activation of ORs by cognate odorants transactivated the M3-R in the absence of its agonist. The crosstalk between ORs and the M3-R suggests that the functional coupling of ORs and the M3-R is required for robust OR activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.