ReviewThe Journal of physiology2011
Regulation of gene expression by carbon dioxide.
Review in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Carbon dioxide levels in neonates: what are safe parameters?Pediatric research · 2022Pooled it
- The Contribution of Aerospace Medicine Specialty Expertise in the Diagnosis and Treatment of Headache Disorders with Concomitant Clinically Symptomatic Dyscapnia (Respiratory Alkalosis/Acidosis).Current neurology and neuroscience reports · 2025Review
- Carbon dioxide enhances Akkermansia muciniphila fitness and anti-obesity efficacy in high-fat diet mice.The ISME journal · 2025Article
- Production of Peroxymonocarbonate by Steady-State Micromolar HChemical research in toxicology · 2024Article
- Near atmospheric carbon dioxide activates plant ubiquitin cross-linking.BBA advances · 2023Article
- Interplay of carbon dioxide and peroxide metabolism in mammalian cells.The Journal of biological chemistry · 2022Review
- Site-Specific Detection and Characterization of Ubiquitin Carbamylation.Biochemistry · 2022Article
- Hypercapnia Regulates Gene Expression and Tissue Function.Frontiers in physiology · 2020Review
- Elevated COScientific reports · 2019Article
- Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into COThe Journal of biological chemistry · 2017Article
- Hypoxia-dependent regulation of inflammatory pathways in immune cells.The Journal of clinical investigation · 2016Review
- Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia.The Journal of biological chemistry · 2016Article
- Extracellular hemoglobin: the case of a friend turned foe.Frontiers in physiology · 2015Review
- Article
- Carbon dioxide-sensing in organisms and its implications for human disease.Cellular and molecular life sciences : CMLS · 2014Review
- Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Monitoring states of altered carbohydrate metabolism via breath analysis: are times ripe for transition from potential to reality?Current opinion in clinical nutrition and metabolic care · 2013Review
- CrossTalk opposing view: there is not added benefit to providing permissive hypercapnia in the treatment of ARDS.The Journal of physiology · 2013Article
- The clinical potential of exhaled breath analysis for diabetes mellitus.Diabetes research and clinical practice · 2012Review
- Elevated carbon dioxide blunts mammalian cAMP signaling dependent on inositol 1,4,5-triphosphate receptor-mediated Ca2+ release.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon dioxide (CO(2)) is a physiological gas found at low levels in the atmosphere and produced in cells during the process of aerobic respiration. Consequently, the levels of CO(2) within tissues are usually significantly higher than those found externally. Shifts in tissue levels of CO(2) (leading to either hypercapnia or hypocapnia) are associated with a number of pathophysiological conditions in humans and can occur naturally in niche habitats such as those of burrowing animals. Clinical studies have indicated that such altered CO(2) levels can impact upon disease progression. Recent advances in our understanding of the biology of CO(2) has shown that like other physiological gases such as molecular oxygen (O(2)) and nitric oxide (NO), CO(2) levels can be sensed by cells resulting in the initiation of physiological and pathophysiological responses. Acute CO(2) sensing in neurons and peripheral and central chemoreceptors is important in rapidly activated responses including olfactory signalling, taste sensation and cardiorespiratory control. Furthermore, a role for CO(2) in the regulation of gene transcription has recently been identified with exposure of cells and model organisms to high CO(2) leading to suppression of genes involved in the regulation of innate immunity and inflammation. This latter, transcriptional regulatory role for CO(2), has been largely attributed to altered activity of the NF-B family of transcription factors. Here, we review our evolving understanding of how CO(2) impacts upon gene transcription.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.