ReviewThe Journal of physiology2011
'Integrative Physiology 2.0': integration of systems biology into physiology and its application to cardiovascular homeostasis.
Review in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- An ecophysiological approach to improving health outcomes of ornamental shrimp during aquarium trade and transportation.Conservation physiology · 2026Article
- Association between Mean Heart Rate and Recurrence Quantification Analysis of Heart Rate Variability in End-Stage Renal Disease.Entropy (Basel, Switzerland) · 2020Article
- The Redox architecture of physiological function.Current opinion in physiology · 2019Review
- Conceptual Foundations of Systems Biology Explaining Complex Cardiac Diseases.Healthcare (Basel, Switzerland) · 2017Review
- The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics.Cardiology research and practice · 2017Review
- The Future of Cardiovascular Epidemiology.Circulation · 2016Review
- Animal and in silico models for the study of sarcomeric cardiomyopathies.Cardiovascular research · 2015Review
- Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline.Progress in biophysics and molecular biology · 2014Article
- Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. II. Impact of exercise training in obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Translational physiology: from molecules to public health.The Journal of physiology · 2013Review
- The new biology: a bridge to clinical cardiology.Hippokratia · 2012Article
- Analyses of Brucella pathogenesis, host immunity, and vaccine targets using systems biology and bioinformatics.Frontiers in cellular and infection microbiology · 2012Review
- Giant sucking sound: can physiology fill the intellectual void left by the reductionists?Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Impact of exercise training on endothelial transcriptional profiles in healthy swine: a genome-wide microarray analysis.American journal of physiology. Heart and circulatory physiology · 2011Article
- Physiology: alone at the bottom, alone at the top.The Journal of physiology · 2011Article
- ASSOCIATION BETWEEN LEISURE TIME AND COMMUTING PHYSICAL ACTIVITIES WITH HEART RATE VARIABILITY IN MALE ADOLESCENTS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao PauloArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the completion of the Human Genome Project and the advent of the large scaled unbiased '-omics' techniques, the field of systems biology has emerged. Systems biology aims to move away from the traditional reductionist molecular approach, which focused on understanding the role of single genes or proteins, towards a more holistic approach by studying networks and interactions between individual components of networks. From a conceptual standpoint, systems biology elicits a 'back to the future' experience for any integrative physiologist. However, many of the new techniques and modalities employed by systems biologists yield tremendous potential for integrative physiologists to expand their tool arsenal to (quantitatively) study complex biological processes, such as cardiac remodelling and heart failure, in a truly holistic fashion. We therefore advocate that systems biology should not become/stay a separate discipline with '-omics' as its playing field, but should be integrated into physiology to create 'Integrative Physiology 2.0'.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.