ArticleThe Journal of physiology2011
Presynaptic action potential waveform determines cortical synaptic latency.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 72 citations in OpenAlex.
- Coordinated regulation of timing and strength of synaptic outputs by adrenergic receptors through control of action potentials in Purkinje cells.Frontiers in cellular neuroscience · 2025Article
- Spike-timing-dependent plasticity offers delay-gated oscillatory potentiation for autaptic weights.Frontiers in neural circuits · 2025Article
- Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathy.JCI insight · 2024Article
- Enhanced Release Probability without Changes in Synaptic Delay during Analogue-Digital Facilitation.Cells · 2024Article
- Stronger stimulus triggers synaptic transmission faster through earlier started action potential.Cell communication and signaling : CCS · 2024Article
- Extreme value statistics of nerve transmission delay.PloS one · 2024Article
- Rescue of Normal Excitability in LGI1-Deficient Epileptic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- An automated method for precise axon reconstruction from recordings of high-density micro-electrode arrays.Journal of neural engineering · 2022Article
- Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome.Cell reports · 2022Article
- Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Voltage-Gated Potassium Channels Ensure Action Potential Shape Fidelity in Distal Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The potassium channel subunit KProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Axonal NaScience advances · 2020Article
- Subcellular control of membrane excitability in the axon.Current opinion in neurobiology · 2019Review
- The Role of CaCell reports · 2019Article
- Technologies to Study Action Potential Propagation With a Focus on HD-MEAs.Frontiers in cellular neuroscience · 2019Article
- A Delay Learning Algorithm Based on Spike Train Kernels for Spiking Neurons.Frontiers in neuroscience · 2019Article
- Article
- mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic latency at cortical synapses is determined by the presynaptic release probability (Pr). Short- and long-term presynaptic plasticity is associated with modulation of synaptic delay. We show here that the duration and amplitude of the presynaptic action potential also determine synaptic latency at neocortical and hippocampal excitatory synapses. Blockade of voltage-gated potassium (Kv) channels with 4-aminopyridine or dendrotoxin-I, but not tetraethylammonium, induced a 1–2 ms shift in latency at excitatory synaptic connections formed by pairs of neocortical pyramidal neurons. 4-Aminopyridine or dendrotoxin-I, but not tetraethylammonium, increased the duration of the action potential recorded in the axon, suggesting that presynaptic spike duration is controlled by axonal Kv1 potassium channels. Spike width-dependent changes in latency have been identified at the mossy fibre–CA3 cell synapses and contribute to stabilization of synaptic timing during repetitive stimulation. The effects of presynaptic spike amplitude on synaptic latency were also examined. Decreasing the amplitude of the presynaptic action potential with 15–30 nm TTX reduced synaptic latency by ∼0.5 ms. The regulation of synaptic timing by potassium and sodium channel blockers could not be attributed to modulation of axonal conduction. Rather, these effects are compatible with modifications of the kinetics of the presynaptic calcium current. We conclude that synaptic latency at cortical neurons is not constant but dynamically regulated by presynaptic action potential waveform.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.