ArticleThe Journal of physiology2011
Astrocytes control GABAergic inhibition of neurons in the mouse barrel cortex.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
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- Fully flexible implantable neural probes for electrophysiology recording and controlled neurochemical modulation.Microsystems & nanoengineering · 2024Article
- Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents.Scientific reports · 2023Article
- Spatial organization of neuron-astrocyte interactions in the somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Spinal Cord Injury and Loss of Cortical Inhibition.International journal of molecular sciences · 2022Review
- Astrocytes modulate sensory-evoked neuronal network activity.Nature communications · 2020Article
- Mechanism of Manganese Dysregulation of Dopamine Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Astrocytes-The Ultimate Effectors of Long-Range Neuromodulatory Networks?Frontiers in cellular neuroscience · 2020Article
- General Pathophysiology of Astroglia.Advances in experimental medicine and biology · 2019Review
- Versatile control of synaptic circuits by astrocytes: where, when and how?Nature reviews. Neuroscience · 2018Review
- Endocannabinoids in Body Weight Control.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome.eLife · 2018Article
- Translational potential of astrocytes in brain disorders.Progress in neurobiology · 2016Review
- Loss of the calcium channel β4 subunit impairs parallel fibre volley and Purkinje cell firing in cerebellum of adult ataxic mice.The European journal of neuroscience · 2016Article
- Enteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases.Inflammatory bowel diseases · 2016Review
- Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study.Neural plasticity · 2016Article
- MiRNAs in Astrocyte-Derived Exosomes as Possible Mediators of Neuronal Plasticity.Journal of experimental neuroscience · 2016Article
- Astroglial calcium signaling displays short-term plasticity and adjusts synaptic efficacy.Frontiers in cellular neuroscience · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astrocytes in the barrel cortex respond with a transient Ca2+ increase to neuronal stimulation and this response is restricted to the stimulated barrel field. In the present study we suppressed the astrocyte response by dialysing these cells with the Ca2+ chelator BAPTA. Electrical stimulation triggered a depolarization in stellate or pyramidal ‘regular spiking' neurons from cortex layer 4 and 2/3 and this response was augmented in amplitude and duration after astrocytes were dialysed with BAPTA. Combined blockade of GABAA and GABAB receptors mimicked the effect of BAPTA dialysis, while glutamate receptor blockers had no effect. Moreover, the frequency of spontaneous postsynaptic currents was increased after BAPTA dialysis. Outside the range of BAPTA dialysis astrocytes responded with a Ca2+ increase, but in contrast to control, the response was no longer restricted to one barrel field. Our findings indicate that astrocytes control neuronal inhibition in the barrel cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.