ArticleThe American journal of pathology2011
Interaction of a specific population of human embryonic stem cell-derived progenitor cells with CD11b+ cells ameliorates sepsis-induced lung inflammatory injury.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Cell therapy for the treatment of sepsis and acute respiratory distress syndrome.Annals of translational medicine · 2017Review
- Stem/progenitor cells in endogenous repairing responses: new toolbox for the treatment of acute lung injury.Journal of translational medicine · 2016Review
- Endothelial progenitor cells and a stromal cell-derived factor-1α analogue synergistically improve survival in sepsis.American journal of respiratory and critical care medicine · 2014Article
- Article
- Stem cells, cell therapies, and bioengineering in lung biology and diseases. Comprehensive review of the recent literature 2010-2012.Annals of the American Thoracic Society · 2013Review
- Lung transplantation.F1000prime reports · 2013Article
- Endothelial progenitor cells: the promise of cell-based therapies for acute lung injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Review
- Clinical review: Stem cell therapies for acute lung injury/acute respiratory distress syndrome - hope or hype?Critical care (London, England) · 2012Review
- TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation.The Journal of experimental medicine · 2012Article
- Resolution of acute lung injury and inflammation: a translational mouse model.The European respiratory journal · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Human embryonic stem cells differentiated under mesoderm-inducing conditions have important therapeutic properties in sepsis-induced lung injury in mice. Single cell suspensions obtained from day 7 human embryoid bodies (d7EBs) injected i.v. 1 hour after cecal ligation and puncture significantly reduced lung inflammation and edema as well as production of tumor necrosis factor-α and interferon-γ in lungs compared with controls, whereas interleukin-10 production remained elevated. d7EB cell transplantation also reduced mortality to 50% from 90% in the control group. The protection was ascribed to d7EB cell interaction with lung resident CD11b+ cells, and was correlated with the ability of d7EB cells to reduce it also reduced production of proinflammatory cytokines by CD11+ cells, and to endothelial NO synthase-derived NO by d7EB cells, leading to inhibition of inducible macrophage-type NO synthase activation in CD11b+ cells. The protective progenitor cells were positive for the endothelial and hematopoietic lineage marker angiotensin converting enzyme (ACE). Only the ACE+ fraction modulated the proinflammatory profile of CD11b+ cells and reduced mortality in septic mice. In contrast to the nonprotective ACE-cell fraction, the ACE+ cell fraction also produced NO. These findings suggest that an ACE+ subset of human embryonic stem cell-derived progenitor cells has a highly specialized anti-inflammatory function that ameliorates sepsis-induced lung inflammation and reduces mortality.
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Registered trials
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