ArticleThe American journal of pathology2011
Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 74 citations in OpenAlex.
- Chlamydia trachomatis serovar D replicates in uroepithelial T24/83 cells in the absence of overt inflammation.Scientific reports · 2026Article
- An Exploratory In Silico Analysis ofCancers · 2026Article
- Prevalence and risk factors for laparoscopic managed ectopic pregnancies at a tertiary referral hospital - a 10-year synopsis: a cross sectional study.BMC pregnancy and childbirth · 2026Article
- Study Models forMicroorganisms · 2025Review
- IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube.Nature communications · 2024Article
- Bioengineered Co-culture of organoids to recapitulate host-microbe interactions.Materials today. Bio · 2022Review
- Association between Chlamydial Infection with Ectopic and Full-Term Pregnancies: A Case-Control Study.Tropical medicine and infectious disease · 2022Article
- Article
- Association Between aFrontiers in genetics · 2021Article
- Non-Frontiers in cellular and infection microbiology · 2021Article
- A post-invasion role forThe Journal of biological chemistry · 2020Article
- Organoid technology in female reproductive biomedicine.Reproductive biology and endocrinology : RB&E · 2020Review
- Tubal ectopic pregnancy occurrence is associated with high expressions of prokineticin receptors and aberrant secretion of inflammatory cytokines.American journal of translational research · 2020Article
- Second Trimester Heterotopic Triplet Pregnancy with Intrauterine Twin Pregnancy and Ruptured Interstitial Pregnancy: A Maternal Near-Miss Case Report.Case reports in obstetrics and gynecology · 2020Article
- Toll-Like Receptor 3 Deficiency Leads to Altered Immune Responses to Chlamydia trachomatis Infection in Human Oviduct Epithelial Cells.Infection and immunity · 2019Article
- Effect of Time of Day of Infection on Chlamydia Infectivity and Pathogenesis.Scientific reports · 2019Article
- Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation.Nature communications · 2019Article
- A renewed tool kit to exploreF1000Research · 2019Review
- Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment.EBioMedicine · 2018Article
- The Diagnosis and Treatment of Ectopic Pregnancy.Deutsches Arzteblatt international · 2015Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations are not completely understood. Fallopian tube (FT) from women with EP exhibit altered expression of prokineticin receptors 1 and 2 (PROKR1 and PROKR2); smoking increases FT PROKR1, resulting in a microenvironment predisposed to EP. We hypothesize that C. trachomatis also predisposes to EP by altering FT PROKR expression and have investigated this by examining NFκB activation via ligation of the Toll-like receptor (TLR) family of cell-surface pattern recognition receptors. PROKR2 mRNA was higher in FT from women with evidence of past C. trachomatis infection than in those without (P < 0.05), and was also increased in FT explants and in oviductal epithelial cell line OE-E6/E7 infected with C. trachomatis (P < 0.01) or exposed to UV-killed organisms (P < 0.05). The ability of both live and dead organisms to induce this effect suggests ligation of a cell-surface-expressed receptor. FT epithelium and OE-E6/E7 were both found to express TLR2 and TLR4 by immunohistochemistry. Transfection of OE-E6/E7 cells with dominant-negative TLR2 or IκBα abrogated the C. trachomatis-induced PROKR2 expression. We propose that ligation of tubal TLR2 and activation of NFκB by C. trachomatis leads to increased tubal PROKR2, thereby predisposing the tubal microenvironment to ectopic implantation.
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