ArticleThe American journal of pathology2011
Determining prostate cancer-specific death through quantification of stromogenic carcinoma area in prostatectomy specimens.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
- Review
- Article
- Article
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- Histologically Overt Stromal Response and the Risk of Progression after Radical Prostatectomy for Prostate Cancer.Cancers · 2024Article
- Nondestructive 3D pathology with analysis of nuclear features for prostate cancer risk assessment.The Journal of pathology · 2023Article
- "Stromal cells in prostate cancer pathobiology: friends or foes?"British journal of cancer · 2023Review
- Androgen receptor variant-7 regulation by tenascin-c induced src activation.Cell communication and signaling : CCS · 2022Article
- Development and validation of a quantitative reactive stroma biomarker (qRS) for prostate cancer prognosis.Human pathology · 2022Article
- ELF3 mediates IL-1α induced differentiation of mesenchymal stem cells to inflammatory iCAFs.Stem cells (Dayton, Ohio) · 2021Article
- Multiphoton Microscopy for Identifying Collagen Signatures Associated with Biochemical Recurrence in Prostate Cancer Patients.Journal of personalized medicine · 2021Article
- Stromal reactivity differentially drives tumour cell evolution and prostate cancer progression.Nature ecology & evolution · 2020Article
- Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer.Clinical epigenetics · 2020Article
- Heterogeneity of human prostate carcinoma-associated fibroblasts implicates a role for subpopulations in myeloid cell recruitment.The Prostate · 2020Article
- The potential of tumour microenvironment markers to stratify the risk of recurrence in prostate cancer patients.PloS one · 2020Article
- Development of a predictive model for stromal content in prostate cancer samples to improve signature performance.The Journal of pathology · 2019Article
- Inhibition of Nox4-dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal-mediated protumorigenic interactions.International journal of cancer · 2018Article
- The Stromal Niche for Epithelial Stem Cells: A Template for Regeneration and a Brake on Malignancy.Cancer cell · 2017Review
- Review
- Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer.Disease models & mechanisms · 2017Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
We previously reported that reactive stroma grading in prostate cancer (PCa) is predictive of biochemical recurrence in prostatectomies and biopsies. In this study, we tested whether quantifying the percentage of reactive stromal grade 3 (RSG 3; stromogenic carcinoma pattern) in the entire tumor is predictive of PCa-specific death. Whole-mount prostatectomies operated by a single surgeon obtained between 1983 and 1998 were reviewed. Reactive stroma was evaluated as described previously, and areas of RSG 3 in the entire tumor were registered as percentages of total tumor. Statistical analysis was performed using Spearman, Kaplan-Meier, and Cox analyses. In all, 872 cases were evaluable. Quantification of RSG 3 percentage was an independent predictor of biochemical recurrence, analyzed as a continuous or grouped variable. Patients with higher RSG 3 percentages (larger tumor areas with RSG 3) had a significantly decreased biochemical recurrence-free survival than those with a lower RSG 3 percentage, even within the Gleason score 7 subset of patients. A nomogram introduced this new variable to the model. Furthermore, quantification of RSG 3 percentage was significantly predictive of PCa-specific death. Quantification of the RSG 3 (stromogenic carcinoma) area in PCa provides additional novel information on prognosis. These data substantiate the concept that the tumor microenvironment holds significant predictive information, as well as biological significance.
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Registered trials
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