Evidence map›Paper›PMID 21223965›Full record

ReviewExperimental cell research2011

Chemokines in health and disease.

Dayanidhi Raman, Tammy Sobolik-Delmaire, Ann Richmond

Abstract readReview
In one paragraph

Review in Experimental cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 1 synthesis or guideline pooled it, 363 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Interleukin-8 in health and disease.Molecular biomedicine · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Current research in microbial sciences · 2025
    Article
  14. Synthesis of Sulfated Carbohydrates - Glycosaminoglycans.Handbook of experimental pharmacology · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dayanidhi RamanDepartment of Cancer Biology, Vanderbilt University, School of Medicine, USA.
Tammy Sobolik-Delmaire
Ann Richmond
Vanderbilt University · USNashville VA Medical Center · US

Funding

Technologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7M
Translational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2011 to 2025
$18.8M
SNRP PROJECT AT MEHARRY MEDICAL COLLEGEU54NS041071 · NINDS · MEHARRY MEDICAL COLLEGE · PI ANSAH, TWUM A · 2000 to 2008
$9.2M
Targeting the NF-kappaB Pathway in MelanomaR01CA116021 · NCI · VANDERBILT UNIVERSITY · PI RICHMOND, ANN, YAN, CHI · 2005 to 2024
$6.7M
MELANOMA GROWTH STIMULATORY ACTIVITYR01CA034590 · NCI · VANDERBILT UNIVERSITY · PI RICHMOND, ANN · 1986 to 2017
$5.2M
BIOCHEMIISTRY OF A MELANOMA GROWTH STIMULATIONR23CA034590 · NCI · EMORY UNIVERSITY · PI RICHMOND, ANN · 1985 to 1985
–
BLRD VA IK6 BX005225NCI NIH HHS CA34590NCI NIH HHS R01 CA034590NCI NIH HHS R01 CA116021NCI NIH HHS U54 CA163069NIMHD NIH HHS U54 MD007593NINDS NIH HHS U54 NS041071NINDS NIH HHS U54NS041071-6
6 · The paper itself

Abstract

Chemokines and their receptors play a key role in development and homeostasis as well as in the pathogenesis of tumors and autoimmune diseases. Chemokines are involved in the implantation of the early conceptus, the migration of subsets of cells during embryonic development, and the overall growth of the embryo. Chemokines also have an important role in the development and maintenance of innate and adaptive immunity. In addition, they play a significant role in wound healing and angiogenesis. When the physiological role of chemokines is subverted or chronically amplified, disease often follows. Chemokines are involved in the pathobiology of chronic inflammation, tumorigenesis and metastasis, as well as autoimmune diseases. This article reviews the role of chemokines and their receptors in normal and disease processes and the potential for using chemokine antagonists for appropriate targeted therapy.

Indexed as

HealthAnimalsAutoimmune DiseasesChemokinesHumansNeoplasmsReceptors, ChemokineSignal TransductionChemokinesReceptors, Chemokine

Identifiers

PMID21223965
PMCPMC3063402
OpenAlexW2115778648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.