ArticleMolecular neurodegeneration2011
Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD).
Article in Molecular neurodegeneration, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain.Cells · 2023Article
- Human microglial models to study host-virus interactions.Experimental neurology · 2023Review
- Morphine and HIV-1 Tat interact to cause region-specific hyperphosphorylation of tau in transgenic mice.Neuroscience letters · 2021Article
- Microglial responses to peripheral type 1 interferon.Journal of neuroinflammation · 2020Article
- Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, "M-type") KJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Exosomal MiRNA Transfer between Retinal Microglia and RPE.International journal of molecular sciences · 2020Article
- Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro.Journal of neuroinflammation · 2019Article
- AT2R Activation Prevents Microglia Pro-inflammatory Activation in a NOX-Dependent Manner: Inhibition of PKC Activation and p47Molecular neurobiology · 2019Article
- Regulatory role of cytosolic phospholipase AJournal of neuroinflammation · 2017Article
- Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells.Experimental neurobiology · 2016Review
- Cannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed to β Amyloid via Protein Kinase C.Mediators of inflammation · 2016Article
- Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury.Scientific reports · 2015Article
- Mechanisms and potential therapeutic applications of microglial activation after brain injury.CNS neuroscience & therapeutics · 2015Review
- Abdominal obesity contributes to neurocognitive impairment in HIV-infected patients with increased inflammation and immune activation.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- The role of tau protein in HIV-associated neurocognitive disorders.Molecular neurodegeneration · 2014Review
- MiR-155 induction in microglial cells suppresses Japanese encephalitis virus replication and negatively modulates innate immune responses.Journal of neuroinflammation · 2014Article
- The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.Immunology · 2014Review
- Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia.Gene therapy · 2013Article
- Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration.Immunity · 2012Article
- HIV-1 Tat-induced microglial activation and neuronal damage is inhibited via CD45 modulation: A potential new treatment target for HAND.American journal of translational research · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Microglial dysfunction is associated with the pathogenesis and progression of a number of neurodegenerative disorders including HIV associated dementia (HAD). HIV promotion of an M1 antigen presenting cell (APC) - like microglial phenotype, through the promotion of CD40 activity, may impair endogenous mechanisms important for amyloid- beta (Aβ) protein clearance. Further, a chronic pro-inflammatory cycle is established in this manner. CD45 is a protein tyrosine phosphatase receptor which negatively regulates CD40L-CD40-induced microglial M1 activation; an effect leading to the promotion of an M2 phenotype better suited to phagocytose and clear Aβ. Moreover, this CD45 mediated activation state appears to dampen harmful cytokine production. As such, this property of microglial CD45 as a regulatory "off switch" for a CD40-promoted M1, APC-type microglia activation phenotype may represent a critical therapeutic target for the prevention and treatment of neurodegeneration, as well as microglial dysfunction, found in patients with HAD.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.