ArticleReproductive biology and endocrinology : RB&E2011
Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation.
Article in Reproductive biology and endocrinology : RB&E, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 85 citations in OpenAlex.
- Transgenerational effects of in ovo stimulation with synbiotic and choline on gonadal tissue across three generations.Scientific reports · 2025Article
- The role of MicroRNAs as fine-tuners in the onset of puberty: a comprehensive review.Annals of pediatric endocrinology & metabolism · 2024Article
- Integrated miRNA Changes in Canine Testis and Epididymis According to Age and Presence of Cryptorchidism.Animals : an open access journal from MDPI · 2023Article
- Towards a Multi-Omics of Male Infertility.The world journal of men's health · 2023Review
- Role of miRNAs interference on ovarian functions and premature ovarian failure.Cell communication and signaling : CCS · 2022Review
- The Male-Biased Expression of miR-2954 Is Involved in the Male Pathway of Chicken Sex Differentiation.Cells · 2022Article
- A Comprehensive Sequencing Analysis of Testis-Born miRNAs in Immature and Mature Indigenous Wandong Cattle (Genes · 2022Article
- Fetal Estrogens are not Involved in Sex Determination But Critical for Early Ovarian Differentiation in Rabbits.Endocrinology · 2022Article
- Sex-Biased miRNAs in the Gonads of Adult Chinese Alligator (Frontiers in genetics · 2022Article
- MicroRNAs in amniotic fluid and maternal blood plasma associated with sex determination and early gonad differentiation in cattle†.Biology of reproduction · 2021Article
- miRNA Regulatory Functions in Farm Animal Diseases, and Biomarker Potentials for Effective Therapies.International journal of molecular sciences · 2021Review
- MicroRNAs: potential targets and agents of endocrine disruption in female reproduction.Journal of toxicologic pathology · 2019Review
- Roles of microRNAs in mammalian reproduction: from the commitment of germ cells to peri-implantation embryos.Biological reviews of the Cambridge Philosophical Society · 2019Review
- MicroRNAs in ovarian follicular atresia and granulosa cell apoptosis.Reproductive biology and endocrinology : RB&E · 2019Review
- Article
- Comparative transcriptome analysis reveals differentially expressed genes associated with sex expression in garden asparagus (Asparagus officinalis).BMC plant biology · 2017Article
- Identification and profiling of Cyprinus carpio microRNAs during ovary differentiation by deep sequencing.BMC genomics · 2017Article
- Endocrine Regulation in the Ovary by MicroRNA during the Estrous Cycle.Frontiers in endocrinology · 2017Review
- Genome-wide analysis of miRNAs in the ovaries of Jining Grey and Laiwu Black goats to explore the regulation of fecundity.Scientific reports · 2016Article
- MicroRNA Profile of Granulosa Cells after Ovarian Stimulation Differs According to Maturity of Retrieved Oocytes.Geburtshilfe und Frauenheilkunde · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGonadal differentiation in the mammalian fetus involves a complex dose-dependent genetic network. Initiation and progression of fetal ovarian and testicular pathways are accompanied by dynamic expression patterns of thousands of genes. We postulate these expression patterns are regulated by small non-coding RNAs called microRNAs (miRNAs). The aim of this study was to identify the expression of miRNAs in mammalian fetal gonads using sheep as a model.
methodsWe determined the expression of 128 miRNAs by real time PCR in early-gestational (gestational day (GD) 42) and mid-gestational (GD75) sheep ovaries and testes. Expression data were further examined and validated by bioinformatic analysis.
resultsExpression analysis revealed significant differences between ovaries and testes among 24 miRNAs at GD42, and 43 miRNAs at GD75. Bioinformatic analysis revealed that a number of differentially expressed miRNAs are predicted to target genes known to be important in mammalian gonadal development, including ESR1, CYP19A1, and SOX9. In situ hybridization revealed miR-22 localization within fetal testicular cords. As estrogen signaling is important in human and sheep ovarian development, these data indicate that miR-22 is involved in repressing estrogen signaling within fetal testes.
conclusionsBased on our results we postulate that gene expression networks underlying fetal gonadal development are regulated by miRNAs.
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