ArticleMalaria journal2011
Global response of Plasmodium falciparum to hyperoxia: a combined transcriptomic and proteomic approach.
Article in Malaria journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- The Study of Microbial Physiology Under Microoxic Conditions Is Critical but Neglected.Environmental microbiology reports · 2025Review
- Understanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory.PLoS pathogens · 2024Review
- Cultivation of Asexual Intraerythrocytic Stages ofPathogens (Basel, Switzerland) · 2023Review
- Dynamics of parasite growth in genetically diverse Plasmodium falciparum isolates.Molecular and biochemical parasitology · 2023Article
- Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains ModulateMicrobiology spectrum · 2022Article
- The in vivo RNA structurome of the malaria parasite Plasmodium falciparum, a protozoan with an A/U-rich transcriptome.PloS one · 2022Article
- Suitability of methods for Plasmodium falciparum cultivation in atmospheric air.Memorias do Instituto Oswaldo Cruz · 2022Article
- The therapeutic effect of ozonated olive oil plus glucantime on human cutaneous leishmaniasis.Iranian journal of basic medical sciences · 2019Article
- Plasmodium falciparum in vitro continuous culture conditions: A comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle.International journal for parasitology. Drugs and drug resistance · 2017Article
- Understanding the Mechanism of Thermotolerance Distinct From Heat Shock Response Through Proteomic Analysis of Industrial Strains of Saccharomyces cerevisiae.Molecular & cellular proteomics : MCP · 2015Article
- Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro.Disease models & mechanisms · 2014Article
- Article
- Model system to define pharmacokinetic requirements for antimalarial drug efficacy.Science translational medicine · 2013Article
- Article
- Plasmodium falciparum malaria: proteomic studies.Revista Brasileira de terapia intensiva · 2012Article
- Plasmodium falciparum infection-induced changes in erythrocyte membrane proteins.Parasitology research · 2012Article
- Proteomic analysis revealed alterations of theResearch and reports in tropical medicine · 2011Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver its life cycle, the Plasmodium falciparum parasite is exposed to different environmental conditions, particularly to variations in O2 pressure. For example, the parasite circulates in human venous blood at 5% O2 pressure and in arterial blood, particularly in the lungs, at 13% O2 pressure. Moreover, the parasite is exposed to 21% O2 levels in the salivary glands of mosquitoes.
methodsTo study the metabolic adaptation of P. falciparum to different oxygen pressures during the intraerythrocytic cycle, a combined approach using transcriptomic and proteomic techniques was undertaken.
resultsEven though hyperoxia lengthens the parasitic cycle, significant transcriptional changes were detected in hyperoxic conditions in the late-ring stage. Using PS 6.0 ™ software (Ariadne Genomics) for microarray analysis, this study demonstrate up-expression of genes involved in antioxidant systems and down-expression of genes involved in the digestive vacuole metabolism and the glycolysis in favour of mitochondrial respiration. Proteomic analysis revealed increased levels of heat shock proteins, and decreased levels of glycolytic enzymes. Some of this regulation reflected post-transcriptional modifications during the hyperoxia response.
conclusionsThese results seem to indicate that hyperoxia activates antioxidant defence systems in parasites to preserve the integrity of its cellular structures. Moreover, environmental constraints seem to induce an energetic metabolism adaptation of P. falciparum. This study provides a better understanding of the adaptive capabilities of P. falciparum to environmental changes and may lead to the development of novel therapeutic targets.
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