ReviewZoonoses and public health2011
The ecology and pathobiology of Clostridium difficile infections: an interdisciplinary challenge.
Review in Zoonoses and public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- A multicentre randomised controlled trial evaluating lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea in older people admitted to hospital: the PLACIDE study protocol.BMC infectious diseases · 2012Trial
- Pangenome-GWAS analysis ofCanadian journal of microbiology · 2026Article
- Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics.Pharmacological reports : PR · 2023Review
- Genotyping and Antimicrobial Susceptibility ofPathogens (Basel, Switzerland) · 2021Article
- Modeling Clostridium difficile in a hospital setting: control and admissions of colonized and symptomatic patients.Theoretical biology & medical modelling · 2019Article
- Fecal calprotectin concentrations in cancer patients with Clostridium difficile infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Bacteremia and Septic Arthritis due to a Nontoxigenic Strain ofOpen forum infectious diseases · 2018Article
- Optimal control of vaccination rate in an epidemiological model of Clostridium difficile transmission.Journal of mathematical biology · 2017Article
- Faecal microbiota transplantation: a regulatory hurdle?BMC gastroenterology · 2017Review
- A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence.PLoS pathogens · 2016Article
- Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Fecal transplant policy and legislation.World journal of gastroenterology · 2015Article
- Sensitivity to antibiotics of Clostridium difficile toxigenic nosocomial strains.Folia microbiologica · 2014Article
- Markers of intestinal inflammation, not bacterial burden, correlate with clinical outcomes in Clostridium difficile infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Diarrhea etiology in a pediatric emergency department: a case control study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Article
- Toxigenic Clostridium difficile PCR ribotypes from wastewater treatment plants in southern Switzerland.Applied and environmental microbiology · 2012Article
- Isolation and characterization of Clostridium difficile from shellfish and marine environments.Folia microbiologica · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Clostridium difficile is a well recognized pathogen of humans and animals. Although C. difficile was first identified over 70 years ago, much remains unknown in regards to the primary source of human acquisition and its pathobiology. These deficits in our knowledge have been intensified by dramatic increases in both the frequency and severity of disease in humans over the last decade. The changes in C. difficile epidemiology might be due to the emergence of a hypervirulent stain of C. difficile, ageing of the population, altered risk of developing infection with newer medications, and/or increased exposure to C. difficile outside of hospitals. In recent years, there have been numerous reports documenting C. difficile contamination of various foods, and reports of similarities between strains that infect animals and strains that infect humans as well. The purposes of this review are to highlight the many challenges to diagnosing, treating, and preventing C. difficile infection in humans, and to stress that collaboration between human and veterinary researchers is needed to control this pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.