ArticleJournal of periodontology2011
Development of an animal model for Aggregatibacter actinomycetemcomitans biofilm-mediated oral osteolytic infection: a preliminary study.
Article in Journal of periodontology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Methodological Evaluation of Micro-CT Analytical Parameters for Quantifying Bone Loss in a Murine Maxillary Peri-Implantitis Model.Dentistry journal · 2026Article
- The natural human adaptive IgG-specific immune response is skewed towards non-protective tail domains of DNABII proteins.Frontiers in immunology · 2026Article
- Precision immunopharmacology in peri-implantitis management: from molecular mechanisms to advanced therapeutic strategies.Frontiers in immunology · 2026Review
- Biofilms and oral health: nanotechnology for biofilm control.Discover nano · 2025Review
- Characteristics of Si (C,N) Silicon Carbonitride Layers on the Surface of Ni-Cr Alloys Used in Dental Prosthetics.Materials (Basel, Switzerland) · 2024Article
- A novel investigational preclinical model to assess fluence rate for dental oral craniofacial tissues.Photodiagnosis and photodynamic therapy · 2024Article
- Induction of Experimental Peri-Implantitis with Strains Selected from the Human Oral Microbiome.Biomedicines · 2024Article
- A Standardized Rat Model to Study Peri-implantitis of Transmucosal Osseointegrated Implants.Biomaterials research · 2024Article
- Identification of Senescent Cells in Peri-Implantitis and Prevention of Mini-Implant Loss Using Senolytics.International journal of molecular sciences · 2023Article
- Cytotoxicity of dental cement on soft tissue associated with dental implants at different time intervals.F1000Research · 2023Article
- Cytotoxicity of Dental Cements on Soft Tissue Associated with Dental Implants.International journal of dentistry · 2022Article
- Pre-Clinical Models in Implant Dentistry: Past, Present, Future.Biomedicines · 2021Review
- Evaluation of biofilm colonization on multi-part dental implants in a rat model.BMC oral health · 2021Article
- Cellular and Molecular Dynamics during Early Oral Osseointegration: A Comprehensive Characterization in the Lewis Rat.ACS biomaterials science & engineering · 2021Article
- Review
- Residual decontamination chemical agents negatively affect adhesion and proliferation of osteoblast-like cells on implant surface.International journal of implant dentistry · 2020Article
- Is maxillary diastema an appropriate site for implantation in rats?International journal of implant dentistry · 2020Article
- The DNABII family of proteins is comprised of the only nucleoid associated proteins required for nontypeable Haemophilus influenzae biofilm structure.MicrobiologyOpen · 2018Article
- Susceptibility of different mouse strains to peri-implantitis.Journal of periodontal research · 2018Article
- Resolvin E1 Promotes Bone Preservation Under Inflammatory Conditions.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBiofilm-induced inflammatory osteolytic oral infections, such as periodontitis and peri-implantitis, have complex etiology and pathogenesis. A significant obstacle to research has been the lack of appropriate animal models where the inflammatory response to biofilms can be investigated. The aim of this study is to develop a novel animal model to study the host response to Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans)-biofilm colonizing titanium implants.
methodsTitanium implants were inoculated in vitro with A. actinomycetemcomitans, establishing a biofilm for 1 to 3 days. Biofilm-inoculated and control implants were transmucosally placed into rat hard palate or alveolar ridge. Analysis included documentation of clinical inflammation, polymerase chain reaction, and culture detection of A. actinomycetemcomitans and microcomputed tomography quantitation of peri-implant bone volume.
resultsViable A. actinomycetemcomitans biofilm was successfully established on titanium implants in vitro, detected by confocal laser scanning microscopy. An inflammatory response characterized by clinical inflammation, bleeding, ulceration, hyperplasia, and necrosis was observed around biofilm-inoculated implants. A. actinomycetemcomitans was detected by polymerase chain reaction and culture analysis on 100% of biofilm-inoculated implants for up to 3 weeks and 25% for up to 6 weeks. Microcomputed tomography analysis demonstrated significantly lower bone volume (P <0.05) around biofilm-inoculated implants (29.6% ± 7.6%) compared to non-inoculated implants (50.5% ± 9.6%) after 6 weeks.
conclusionsThese results describe a novel animal model where A. actinomycetemcomitans biofilm was established in vitro on titanium implants before placement in rat oral cavity, leading to an inflammatory response, osteolysis, and tissue destruction. This model may have potential use for investigation of host responses to biofilm pathogens and antibiofilm therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.