Trial reportThe journal of physiological sciences : JPS2011
Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle.
Trial report in The journal of physiological sciences : JPS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 90 citations in OpenAlex.
- Acute effects of heated resistance exercise in female and male power athletes.European journal of applied physiology · 2017Trial
- Common and Divergent Physiological Responses to Hypoxia and Heat.Sports medicine (Auckland, N.Z.) · 2026Review
- Heat treatment combined with hybrid exercises retraining mitigates cellular markers of protein turnover after hindlimb suspension in male mice: A pilot study.Experimental physiology · 2026Article
- Review
- Non-ablative transurethral laser treatment for collagen remodeling with functional recovery in an in vivo model of stress urinary incontinence.Scientific reports · 2026Article
- Heat Therapy: Targeting Health, Disease, and Disability.Comprehensive Physiology · 2026Review
- Heat stress in dairy buffalo: biometeorological, molecular, and adaptive strategies for climate change resilience in subtropical regions.Veterinary research communications · 2026Article
- Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans.The Journal of physiology · 2025Article
- Resistance exercise and skeletal muscle: protein synthesis, degradation, and controversies.European journal of applied physiology · 2025Review
- Nutritional interventions in muscle hypertrophy research: a scientometric analysis within the context of resistance training (1992-2025).Journal of health, population, and nutrition · 2025Review
- Effects of thermal interventions on skeletal muscle adaptations and regeneration: perspectives on epigenetics: a narrative review.European journal of applied physiology · 2025Review
- The Simultaneous Application of Synchronized Radiofrequency and HIFES Technology Improves the Tone of Facial Muscles, as Assessed by Ultrasound Echo Intensity: A Pilot Study.Aesthetic surgery journal. Open forum · 2025Article
- Novel Applicator Utilizing HIFES and Enhanced Synchronized Radiofrequency+ for Subcutaneous Fat Reduction: Porcine Model Study.Lasers in surgery and medicine · 2024Article
- A Novel Approach to Shaping the Lateral Abdomen: Simultaneous Application of High-Intensity Focused Electromagnetic (HIFEM) Therapy and Synchronized Radiofrequency at the Flanks: A Multicenter MRI Study.Aesthetic surgery journal · 2024Article
- The combined influences of local heat application and resistance exercise on the acute mRNA response of skeletal muscle.Frontiers in physiology · 2024Article
- Article
- The independent effects of local heat application on muscle growth program associated mRNA and protein phosphorylation.Journal of thermal biology · 2023Article
- Temperature Fluctuations Modulate Molecular Mechanisms in Skeletal Muscle and Influence Growth Potential in Beef Steers.Journal of animal science · 2023Article
- Effect of hot water immersion on acute physiological responses following resistance exercise.Frontiers in physiology · 2023Article
- Genome-Wide Association Study IdentifiesCells · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the effect of heat stress (HS) on mammalian target of rapamycin (mTOR) signaling involved in translation initiation after resistance exercise in human skeletal muscle. Eight young male subjects performed four sets of six maximal repetitions of knee extension exercises, with or without HS, in a randomized crossover design. HS was applied to the belly of the vastus lateralis by using a microwave therapy unit prior to and during exercise. Muscle biopsies were taken from the vastus lateralis before, immediately after, and 1 h after exercise. HS significantly increased the phosphorylation of Akt/PKB, mTOR, and ribosomal protein S6 at 1 h after exercise (P < 0.05), and the 4E-BP1 phosphorylation level, which had initially decreased with exercise, had recovered by 1 h after exercise with HS. In addition, the phosphorylation of ribosomal S6 kinase 1 was significantly increased immediately after exercise with HS (P < 0.05). These results indicate that HS enhances mTOR signaling after resistance exercise in human skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.