ReviewPediatric nephrology (Berlin, Germany)2011
Patterning and early cell lineage decisions in the developing kidney: the role of Pax genes.
Review in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Expansion of human pluripotent stem cell-induced nephron progenitor cells (iNPCs) and the generation of nephron organoids from iNPCs.Nature protocols · 2026Review
- Expression of ENL YEATS domain tumor mutations in nephrogenic or stromal lineage impairs kidney development.Nature communications · 2025Article
- Evolutionary analysis of paired box gene family and biological function exploration ofActa biochimica et biophysica Sinica · 2024Article
- Review
- PAX2 and CAKUT Phenotypes: Report on Two New Variants and a Review of Mutations from the Leiden Open Variation Database.International journal of molecular sciences · 2023Article
- Papillorenal syndrome: a systemic diagnosis not to be missed on funduscopy.BMJ case reports · 2021Article
- Review
- Epigenetic regulation of renal development.Seminars in cell & developmental biology · 2019Review
- MAPK/ERK Signaling in Regulation of Renal Differentiation.International journal of molecular sciences · 2019Review
- Could the interaction between LMX1B and PAX2 influence the severity of renal symptoms?European journal of human genetics : EJHG · 2018Article
- PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition.International urology and nephrology · 2018Article
- Prognostic value of PAX9 in patients with esophageal squamous cell carcinoma and its prediction value to radiation sensitivity.Molecular medicine reports · 2017Article
- Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.Developmental cell · 2017Article
- Concise Review: Understanding the Renal Progenitor Cell Niche In Vivo to Recapitulate Nephrogenesis In Vitro.Stem cells translational medicine · 2015Review
- Epigenetic States of nephron progenitors and epithelial differentiation.Journal of cellular biochemistry · 2015Review
- Evolutionary history of chordate PAX genes: dynamics of change in a complex gene family.PloS one · 2013Article
- Discordant phenotype in monozygotic twins with renal coloboma syndrome and a PAX2 mutation.Pediatric nephrology (Berlin, Germany) · 2012Article
- PAX2 in human kidney malformations and disease.Pediatric nephrology (Berlin, Germany) · 2012Review
- Update of PAX2 mutations in renal coloboma syndrome and establishment of a locus-specific database.Human mutation · 2012Article
- Less expression of prohibitin is associated with increased paired box 2 (PAX2) in renal interstitial fibrosis rats.International journal of molecular sciences · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Specification of the intermediate mesoderm and the epithelial derivatives that will make the mammalian kidney depends on the concerted action of many transcription factors and signaling proteins. Among the earliest genes expressed in the nephric duct and surrounding mesenchyme is Pax2, whose function is essential for making and maintaining the epithelium. The Pax2 protein is subject to phosphorylation in response to signals that activate the c-Jun N-terminal kinase pathway, including Wnts and BMPs. In cell culture systems, Pax2 is know to recruit components of a histone H3 lysine 4 methyltransferase complex to specific DNA sites to alter the pattern of histone modifications and determine gene expression. This epigenetic function may underlie the ability of Pax2 and similar proteins to maintain cell lineages during development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.