ArticleCurrent microbiology2011
Oleanolic and ursolic acids influence affect the expression of the cysteine regulon and the stress response in Escherichia coli.
Article in Current microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Identification of MultipleInternational journal of molecular sciences · 2026Article
- Principal Bioactive Properties of Oleanolic Acid, Its Derivatives, and Analogues.Molecules (Basel, Switzerland) · 2024Review
- Antimicrobial activities and mechanisms of extract and components of herbs in East Asia.RSC advances · 2022Review
- The Synergistic Effect of Triterpenoids and Flavonoids-New Approaches for Treating Bacterial Infections?Molecules (Basel, Switzerland) · 2022Article
- Bacterial Skin Infections in Livestock and Plant-Based Alternatives to Their Antibiotic Treatment.Animals : an open access journal from MDPI · 2021Review
- Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalarial Drug Discovery?Advances in experimental medicine and biology · 2021Article
- Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance.Antibiotics (Basel, Switzerland) · 2020Review
- Pentacyclic triterpenes combined with ciprofloxacin help to eradicate the biofilm formed in vitro by Escherichia coli.The Indian journal of medical research · 2015Article
- Synergistic Effect of Oleanolic Acid on Aminoglycoside Antibiotics against Acinetobacter baumannii.PloS one · 2015Article
- Antimicrobial activity of oleanolic and ursolic acids: an update.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Combating pathogenic microorganisms using plant-derived antimicrobials: a minireview of the mechanistic basis.BioMed research international · 2014Review
- Ursolic acid induces neural regeneration after sciatic nerve injury.Neural regeneration research · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pentacyclic triterpenoids, oleanolic, and ursolic acids, affect peptidoglycan metabolism, altering bacterial morphology, and inhibit the growth and survival of several bacterial species, including pathogenic ones. We investigated the effect of subinhibitory concentrations of these compounds on the expression of three operons from the E. coli cysteine regulon, cysPTWA, cysJIH, and cysB, by using transcriptional fusions with the lacZ reporter gene. An inhibitory effect on β-galactosidase expression directed by all three chromosomal fusions was observed with both compounds. In addition, oleanolic acid, but not ursolic acid, caused a weak increase in DnaK synthesis, suggesting moderate ability of inducing heat-shock response.
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Registered trials
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