ArticleImmunogenetics2011
Characterisation of class II B MHC genes from a ratite bird, the little spotted kiwi (Apteryx owenii).
Article in Immunogenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Low Diversity of Major Histocompatibility Complex (MHC) Genes in Endangered Malayan Tapir (Zoological studies · 2023Article
- Sixteen kiwi (Apteryx spp) transcriptomes provide a wealth of genetic markers and insight into sex chromosome evolution in birds.BMC genomics · 2016Article
- New data from basal Australian songbird lineages show that complex structure of MHC class II β genes has early evolutionary origins within passerines.BMC evolutionary biology · 2016Article
- De novo assembly of the dual transcriptomes of a polymorphic raptor species and its malarial parasite.BMC genomics · 2015Article
- Variation in positively selected major histocompatibility complex class I loci in rufous-collared sparrows (Zonotrichia capensis).Immunogenetics · 2014Article
- Evidence for multiple MHC class II β loci in New Zealand's critically endangered kakapo, Strigops habroptilus.Immunogenetics · 2014Article
- Genetic consequences of a century of protection: serial founder events and survival of the little spotted kiwi (Apteryx owenii).Proceedings. Biological sciences · 2013Article
- MHC class II B diversity in blue tits: a preliminary study.Ecology and evolution · 2013Article
- MHC class IIB exon 2 polymorphism in the Grey partridge (Perdix perdix) is shaped by selection, recombination and gene conversion.PloS one · 2013Article
- Article
- Characterization of MHC class I and II genes in a subantarctic seabird, the blue petrel, Halobaena caerulea (Procellariiformes).Immunogenetics · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex (MHC) genes are important for vertebrate immune response and typically display high levels of diversity due to balancing selection from exposure to diverse pathogens. An understanding of the structure of the MHC region and diversity among functional MHC genes is critical to understanding the evolution of the MHC and species resilience to disease exposure. In this study, we characterise the structure and diversity of class II MHC genes in little spotted kiwi Apteryx owenii, a ratite bird representing the basal avian lineage (paleognaths). Results indicate that little spotted kiwi have a more complex MHC structure than that of other non-passerine birds, with at least five class II MHC genes, three of which are expressed and likely to be functional. Levels of MHC variation among little spotted kiwi are extremely low, with 13 birds assayed having nearly identical MHC genotypes (only two genotypes containing four alleles, three of which are fixed). These results suggest that recent genetic drift due to a species-wide bottleneck of at most seven birds has overwhelmed past selection for high MHC diversity in little spotted kiwi, potentially leaving the species highly susceptible to disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.