ArticleJournal of microbiology (Seoul, Korea)2010
Asc1p, a ribosomal protein, plays a pivotal role in cellular adhesion and virulence in Candida albicans.
Article in Journal of microbiology (Seoul, Korea), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Moonlight-like proteins are actually cell wall components in Pseudocercospora fijiensis.World journal of microbiology & biotechnology · 2023Article
- Characterization of the Secretome of PathogenicPharmaceutics · 2022Article
- Development of Carbazole Derivatives Compounds againstJournal of fungi (Basel, Switzerland) · 2021Article
- Pan-Proteomic Analysis and Elucidation of Protein Abundance among the Closely RelatedBiomolecules · 2020Article
- Chronic Cold Stress Alters the Skin Mucus Interactome in a Temperate Fish Model.Frontiers in physiology · 2018Article
- Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection.BMC systems biology · 2014Article
- Candida albicans, a major human fungal pathogen.Journal of microbiology (Seoul, Korea) · 2011Review
- Roles of Rack1 Proteins in Fungal Pathogenesis.BioMed research internationalReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans, the common human fungal pathogen, can switch morphology from yeast to pseudohyphal or hyphal form upon various environmental cues. It is well-known that the ability of morphological conversion and adhesive growth renders C. albicans virulent. It is noteworthy that every factor involved in the morphogenesis is known to be important for the virulence of this pathogen. To examine a functional relevance of Asc1p, a ribosomal protein, in morphogenesis and virulence, an asc1 homozygous null mutant was generated. Although a normal morphological transition of the asc1 deletion strain in liquid media was found, it did not change its morphology on solid media. Moreover, the adhesion activity and hyphal-specific gene expression were defective due to ASC1 deletion. Finally, it was found that the asc1 null mutant was avirulent in a mouse model. These results strongly suggested that Asc1p a component of the 40S ribosomal subunit and a signal transducer, plays a pivotal role in cellular adhesion and virulence through regulation of specific gene expression in C. albicans.
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Registered trials
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