ArticlePathology oncology research : POR2011
N-myc downstream-regulated gene 1 (NDRG1) a differentiation marker of human breast cancer.
Article in Pathology oncology research : POR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- NDRGs in Breast Cancer: A Review and In Silico Analysis.Cancers · 2024Review
- A review on the role of NDRG1 in different cancers.Molecular biology reports · 2023Review
- Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1.Cancers · 2023Review
- NDRG1 in Cancer: A Suppressor, Promoter, or Both?Cancers · 2022Review
- NDRG1 in Aggressive Breast Cancer Progression and Brain Metastasis.Journal of the National Cancer Institute · 2022Article
- Article
- Expanding Roles of De Novo Lipogenesis in Breast Cancer.International journal of environmental research and public health · 2021Review
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- NDRG1 was downregulated and worked as favorable biomarker in the development of gastric cancer.Translational cancer research · 2020Article
- Oncogenic MNK signalling regulates the metastasis suppressor NDRG1.Oncotarget · 2017Article
- WNT-1 inducible signaling pathway protein-1 enhances growth and tumorigenesis in human breast cancer.Scientific reports · 2015Article
- Frequent MYC coamplification and DNA hypomethylation of multiple genes on 8q in 8p11-p12-amplified breast carcinomas.Oncogenesis · 2014Article
- N-myc downstream-regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review).Oncology letters · 2013Article
- Aberrant NDRG1 methylation associated with its decreased expression and clinicopathological significance in breast cancer.Journal of biomedical science · 2013Article
- Article
- Molecular profiles of pre- and postoperative breast cancer tumours reveal differentially expressed genes.ISRN oncology · 2012Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
N-myc downstream-regulated gene 1 (NDRG1), also called differentiation-related gene-1 (Drg1) and Cap43, is expressed in various normal tissues and suppressed in several malignancies. In this study, whether NDRG1 expression was correlated with differentiation of human breast cancer cells has been investigated. Endogenous expression level of NDRG1 was closely correlated with differentiation status of breast cancer cell lines. Furthermore, sodium butyrate (NaB), an inducer of cellular differentiation, increased the expression of β-casein, a milk-related differentiation marker, together with up-regulation of NDRG1 in breast cancer cells. In contrast, inhibition of NDRG1 by its siRNA resulted in reduced accumulation of β-casein. Immunohistochemical analysis showed co-expression of NDRG1 and β-casein or milk fat protein (MFP), another differentiation marker of breast tissue, in the mouse xenograft model of breast cancer. Furthermore, overexpression of NDRG1 expanded the differentiated area in the xenograft model of breast cancer. In human breast cancer, using samples from 45 patients, we also showed close relationship between NDRG1 and β-casein or MFP expression. Altogether, in vitro and in vivo data demonstrated a possible role of NDRG1 in differentiation of breast cancer. We concluded that NDRG1 could be used as a biomarker for differentiation of breast cancer for both diagnostic and therapeutic purposes.
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