ReviewPathology oncology research : POR2011
Roles of hormones and signaling molecules in describing the relationship between obesity and colon cancer.
Review in Pathology oncology research : POR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Obesity and colorectal cancer risk: A systematic review and meta-analysis.World journal of clinical oncology · 2026Article
- Recent advances in the development and application of colorectal cancer mouse models.Frontiers in pharmacology · 2025Review
- Risk factors for elevated serum colorectal cancer markers in patients with type 2 diabetes mellitus.Open life sciences · 2020Article
- A Review on Dietary Intervention in Obesity Associated Colon CancerAsian Pacific journal of cancer prevention : APJCP · 2019Review
- Adipose tissue inflammation andClinical epigenetics · 2018Article
- Significance of intratissue estrogen concentration coupled with estrogen receptors levels in colorectal cancer prognosis.Oncotarget · 2017Article
- Protective Role of Dietary Berries in Cancer.Antioxidants (Basel, Switzerland) · 2016Review
- Estrogen receptors and their implications in colorectal carcinogenesis.Frontiers in oncology · 2015Review
- Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer.World journal of gastroenterology · 2014Review
- Obesity and colorectal cancer: role of adipokines in tumor initiation and progression.World journal of gastroenterology · 2014Review
- Mechanisms of obesity-induced gastrointestinal neoplasia.Gastroenterology · 2014Review
- Putative role of adipose tissue in growth and metabolism of colon cancer cells.Frontiers in oncology · 2014Review
- Diet induced obesity increases the risk of colonic tumorigenesis in mice.Pathology oncology research : POR · 2013Article
- Risk of colonic cancer is not higher in the obese Lep(ob) mouse model compared to lean littermates.Pathology oncology research : POR · 2013Article
- The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors.Journal of drug delivery · 2013Article
- Obesity and colorectal cancer.Clinics in colon and rectal surgery · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colon cancer represents a highly prevalent disease in the Western world. While dietary and lifestyle recommendations remain important factors in disease prevention and treatment, epidemiological data have made it clear that obesity and excess body weight remain significant risk factors for the disease. A number of potential direct and indirect relationships exist between obesity and increased risk of colon cancer. Several mechanisms which appear promising and warrant further investigation are discussed here, specifically the modifying role of insulin and insulin-like growth factors, leptin, adipose-tissue induced changes in estrogens and androgens, and inflammatory molecules. A brief review of these hormones and signaling molecules and their action in colon cancer development is described. A thorough integration and understanding of the mechanisms of action these systems exert on colonic epithelia will be important in designing studies and experiments aimed at elucidating disease etiology for prevention and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.