ArticlePlanta2011
UV-B-induced DNA damage mediates expression changes of cell cycle regulatory genes in Arabidopsis root tips.
Article in Planta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 59 citations in OpenAlex.
- Cerium oxide nanoparticles ameliorate Arabidopsis thaliana root damage under UV-B stress by modulating the cell cycle and auxin pathways.Protoplasma · 2025Article
- Ultraviolet-B Radiation Represses Primary Root Elongation by Inhibiting Cell Proliferation in the Meristematic Zone of Arabidopsis Seedlings.Frontiers in plant science · 2022Article
- Downsizing in plants-UV light induces pronounced morphological changes in the absence of stress.Plant physiology · 2021Article
- UV-B light and its application potential to reduce disease and pest incidence in crops.Horticulture research · 2021Review
- How can the natural radiation background affect DNA integrity in angiosperm plant species at different altitudes in Rila Mountain (Southwest Bulgaria)?Environmental science and pollution research international · 2019Article
- Tiny Yet Indispensable Plant MicroRNAs Are Worth to Explore as Key Components for Combating Genotoxic Stresses.Frontiers in plant science · 2019Review
- Integration and scaling of UV-B radiation effects on plants: from molecular interactions to whole plant responses.Ecology and evolution · 2016Article
- The use of comet assay in plant toxicology: recent advances.Frontiers in genetics · 2015Review
- Differential responses to high- and low-dose ultraviolet-B stress in tobacco Bright Yellow-2 cells.Frontiers in plant science · 2015Article
- Combined effects of lanthanum(III) and elevated ultraviolet-B radiation on root growth and ion absorption in soybean seedlings.Environmental science and pollution research international · 2014Article
- Repression of growth regulating factors by the microRNA396 inhibits cell proliferation by UV-B radiation in Arabidopsis leaves.The Plant cell · 2013Article
- UV-Induced cell death in plants.International journal of molecular sciences · 2013Review
- UV-B induced morphogenesis: four players or a quartet?Plant signaling & behavior · 2012Article
- Sensing of UV-B radiation by plants.Plant signaling & behavior · 2012Review
- Does cell cycle arrest occur in plant under solar UV-B radiation?Plant signaling & behavior · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though a number of studies have shown that UV-B radiation inhibits plant growth and regulates the cell cycle progress, little is known about the molecular and cellular mechanisms. Here, we developed a synchronous root-tip cell system to investigate expression changes of cell cycle marker genes and DNA damage under UV-B radiation. Expression analysis of cell cycle marker genes revealed that G1-to-S transition in root-tip cells was accomplished within 6 h. In the in vivo synchronous root-tip cells, high level of UV-B radiation (0.45 W m(-2)) induced expression changes of the cell cycle regulatory genes. Genes involved in G1-to-S transition, Histone H4 and E2Fa, were down-regulated by UV-B radiation during 2-6 h; whereas transcripts for KRP2, a negative regulator of G1-to-S transition, were up-regulated by UV-B at 2 h. The peak time for transcript level of CYCD3;1, a positive factor in G1-to-S transition, was delayed by UV-B radiation. Interestingly, a medium level of UV-B radiation (0.25 W m(-2)) did not change the expression of these genes in root tip cells from wild type. However, cell cycle regulatory genes were greatly affected in uvh1 mutant, which exhibited higher content of cyclobutane pyrimidine dimers (CPDs). Ascorbic acid treatment did not change the expression pattern of cell cycle regulatory genes that were affected by high-level UV-B. Our results implied that UV-B-induced DNA damage results in the delay of G1-to-S transition of plant cell cycle. UV-B-induced G1-to-S arrest may be a protective mechanism that prevents cells with damaged DNA from dividing and may explain the plant growth inhibition under increased solar UV-B radiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.