ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2011
Nifedipine alters the light-rise of the electro-oculogram in man.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Review of the clinical electrooculogram - Part 1: Mechanism of the Light-Rise.Documenta ophthalmologica. Advances in ophthalmology · 2026Review
- Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies.Frontiers in neuroscience · 2023Review
- The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.Pharmacological reviews · 2015Review
- Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects.Journal of cellular and molecular medicine · 2013Review
- Role of bestrophin-1 in store-operated calcium entry in retinal pigment epithelium.Pflugers Archiv : European journal of physiology · 2013Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine if the L-type calcium channel participates in the generation of the light-rise of the electro-oculogram (EOG) in man. The aim was to use nifedipine, a specific, L-type calcium channel inhibitor and determine the effects on the light-rise of the EOG in healthy participants.
methodsThe EOG was recorded in 14 participants before and after a 10 mg oral dose of fast-acting nifedipine. The Arden index, time to peak of the EOGs and pulse were recorded before and after ingestion of nifedipine. The test-retest variability of the EOG's light-rise in the absence of nifedipine was performed on 11 of the participants. The mean ± SEM oral dose was 147 ± 9 μg/kg. Scotopic electroretinograms (ERGs) were recorded at four intensities (0.0067, 0.0849, 0.364 and 1.140 cd.s.m⁻²) in six participants before and after a 10 mg oral dose of nifedipine.
resultsThe light-rise of the EOG was significantly reduced in five participants by -22.80 ± 5.6% (p = 0.021), whilst in four of the participants the light-rise increased by +15.7 ± 1.9% (p = 0.033). The results of the test-retest EOGs showed a range of -9.1 to +9.8% Arden index in the absence of nifedipine. Thus, the responses of five participants were not included in the analysis, as the change in the EOG with nifedipine was within this range. The differences in the time to peak of the light-rise were not significantly different in those that showed an increase (p = 0.33) or a decrease (p = 0.87) in the EOG after nifedipine. Pulse rate was not significantly different after nifedipine in the group that showed an increased light-rise (p = 0.77) or in those whose light-rise fell after nifedipine (p = 0.33). No significant effect was observed on the a- and b-wave amplitudes and implicit times for the scotopic components of the scotopic ERG.
conclusionsThe L-type calcium channel contributes to the light-rise of the EOG in man.
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