ArticleJournal of mathematical biology2011
Model of cell signal transduction in a three-dimensional domain.
Article in Journal of mathematical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Cellular diffusion processes in singularly perturbed domains.Journal of mathematical biology · 2024Review
- Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor-ligand interactions in signalling response mechanisms.Journal of mathematical biology · 2014Article
- Dynamics and stability of a three-dimensional model of cell signal transduction.Journal of mathematical biology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Intracellular signalling molecules form pathways inside the cell. These pathways carry a signal to target proteins which results in cellular responses. We consider a spherical cell with two internal compartments containing localized activating enzymes where as deactivating enzymes are spread uniformly through out the cytosol. Two diffusible signalling molecules are activated at the compartments and later deactivated in the cytosol due to deactivating enzymes. The two signalling molecules are a single link in a cascade reaction and form a self regulated dynamical system involving positive and negative feedback. Using matched asymptotic expansions we obtain approximate solutions of the steady state diffusion equation with a linear decay rate. We obtain three-dimensional concentration profiles for the signalling molecules. We also investigate an extension of the above system which has multiple cascade reactions occurring between multiple signalling molecules. Numerically, we show that the speed of the signal is an increasing function of the number of links in the cascade.
Indexed as
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21221588What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.