ArticleNeuroradiology2011
Diffusion-weighted imaging and magnetic resonance spectroscopy of sporadic Creutzfeldt-Jakob disease: correlation with clinical course.
Article in Neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic value of diffusion-weighted brain magnetic resonance imaging in patients with sporadic Creutzfeldt-Jakob disease: a systematic review and meta-analysis.European radiology · 2021Pooled it
- Evolution of Diffusion-Weighted Magnetic Resonance Imaging Signal Abnormality in Sporadic Creutzfeldt-Jakob Disease, With Histopathological Correlation.JAMA neurology · 2016Trial
- Characteristics of Creutzfeldt-Jakob disease at Siriraj Hospital, Thailand: Case series and literature review.Clinical parkinsonism & related disorders · 2024Article
- Case report: 10-year follow-up of a patient with neuronal intranuclear inclusion disease and a literature review.Frontiers in neuroscience · 2024Article
- Longitudinal course of hyperintensity on diffusion weighted imaging in adult-onset neuronal intranuclear inclusion disease patients.Frontiers in neurology · 2023Article
- Role of Biomarkers for the Diagnosis of Prion Diseases: A Narrative Review.Medicina (Kaunas, Lithuania) · 2022Review
- [Sporadic Creutzfeldt-Jakob disease imitates posterior reversible encephalopathy syndrome].Der Nervenarzt · 2019Article
- A long time radiological follow-up of neuronal intranuclear inclusion disease: Two case reports.Medicine · 2018Article
- Neuroradiology of human prion diseases, diagnosis and differential diagnosis.La Radiologia medica · 2017Review
- Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study.NeuroImage. Clinical · 2017Article
- In Vivo Longitudinal (1)H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T.Neurochemical research · 2015Article
- Bilateral symmetrical basal ganglia and thalamic lesions in children: an update (2015).Neuroradiology · 2015Review
- Diffusion-weighted MRI findings and clinical correlations in sporadic Creutzfeldt-Jakob disease.Journal of neurology · 2015Article
- A study of clinical profile, radiological and electroencephalographic characteristics of suspected Creutzfeldt-Jakob disease in a tertiary care centre in South India.Journal of neurosciences in rural practice · 2015Article
- Neuroimaging biomarkers of neurodegenerative diseases and dementia.Seminars in neurology · 2013Review
- Illustrating the relevance of updated diagnostic criteria for sporadic Creutzfeldt-Jakob disease: a teaching neurocase.BMJ case reports · 2013Article
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Authors and funding
5 authors.
Funding
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Abstract
introductionSporadic Creutzfeldt-Jakob disease (sCJD) is a fatal disease with variable clinical courses. The presence or absence of basal ganglia (BG) involvement has been reported to be associated with clinical course. We investigated the association of clinical course of sCJD with diffusion-weighted imaging (DWI) and MR spectroscopy (MRS) as well as BG involvement at early stage.
methodsDWI and single voxel proton MRS were performed in 14 patients with sCJD during the initial diagnostic workup. Apparent diffusion coefficient (ADC) and metabolites were measured in medial occipitoparietal cortices where large hyperintense DWI lesions were found in all patients. The presence or absence of BG involvement, ADC, N-acetylaspartate (NAA)/creatine (Cr) ratios, and choline (Cho)/Cr ratios were correlated with disease duration (i.e., the time from the symptom onset to death).
resultsThe disease duration ranged from 2 to 31 months (median, 16). Hyperintense DWI lesions were observed bilaterally in both cortices and basal ganglia in eight patients and in cortices alone in six patients. Patients with BG involvement had shorter disease duration (median, 6.8 versus 20.5; p = 0.039) than those without and lower NAA/Cr ratios (median, 1.41 versus 2.03; p = 0.001). ADC and Cho/Cr ratios were not significantly different between the patients with BG involvement and those without. By multiple regression analysis, NAA/Cr ratios had the greatest correlation with the disease duration (p = 0.029).
conclusionThe disease duration of sCJD was variable. NAA/Cr ratios of the affected brain at the early stage of sCJD can be used as a useful parameter in predicting the clinical course.
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