ArticlemBio2011
Utilization of the mating scaffold protein in the evolution of a new signal transduction pathway for biofilm development.
Article in mBio, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Echinocandin Adaptation inJournal of fungi (Basel, Switzerland) · 2025Article
- How Do Phages Disrupt the Structure ofInternational journal of molecular sciences · 2023Article
- Signal-mediated localization of Candida albicans pheromone response pathway components.G3 (Bethesda, Md.) · 2021Article
- Unraveling HowJournal of fungi (Basel, Switzerland) · 2020Review
- Protein-Protein Interactions inFrontiers in microbiology · 2019Review
- Protocol for Identifying Natural Agents That Selectively Affect Adhesion, Thickness, Architecture, Cellular Phenotypes, Extracellular Matrix, and Human White Blood Cell Impenetrability of Candida albicans Biofilms.Antimicrobial agents and chemotherapy · 2017Article
- Plasticity of Candida albicans Biofilms.Microbiology and molecular biology reviews : MMBR · 2016Review
- Role of Tec1 in the development, architecture, and integrity of sexual biofilms of Candida albicans.Eukaryotic cell · 2015Article
- Ste18p is a positive control element in the mating process of Candida albicans.Eukaryotic cell · 2014Article
- The role of phenotypic switching in the basic biology and pathogenesis of Candida albicans.Journal of oral microbiology · 2014Review
- Ser or Leu: structural snapshots of mistranslation in Candida albicans.Frontiers in molecular biosciences · 2014Review
- Impact of environmental conditions on the form and function of Candida albicans biofilms.Eukaryotic cell · 2013Article
- Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/α biofilms.Eukaryotic cell · 2013Article
- Activation of the Cph1-dependent MAP kinase signaling pathway induces white-opaque switching in Candida albicans.PLoS pathogens · 2013Article
- Alternative mating type configurations (a/α versus a/a or α/α) of Candida albicans result in alternative biofilms regulated by different pathways.PLoS biology · 2011Article
- Fungal mating pheromones: choreographing the dating game.Fungal genetics and biology : FG & B · 2011Review
- Self-induction of a/a or alpha/alpha biofilms in Candida albicans is a pheromone-based paracrine system requiring switching.Eukaryotic cell · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among the hemiascomycetes, only Candida albicans must switch from the white phenotype to the opaque phenotype to mate. In the recent evolution of this transition, mating-incompetent white cells acquired a unique response to mating pheromone, resulting in the formation of a white cell biofilm that facilitates mating. All of the upstream components of the white cell response pathway so far analyzed have been shown to be derived from the ancestral pathway involved in mating, except for the mitogen-activated protein (MAP) kinase scaffold protein, which had not been identified. Here, through binding and mutational studies, it is demonstrated that in both the opaque and the white cell pheromone responses, Cst5 is the scaffold protein, supporting the evolutionary scenario proposed. Although Cst5 plays the same role in tethering the MAP kinases as Ste5 does in Saccharomyces cerevisiae, Cst5 is approximately one-third the size and has only one rather than four phosphorylation sites involved in activation and cytoplasmic relocalization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.