ArticleCell research2011
Transcriptional activation of endoplasmic reticulum chaperone GRP78 by HCMV IE1-72 protein.
Article in Cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Human Cytomegalovirus IE1 Impairs Neuronal Migration by Downregulating Connexin 43.Journal of virology · 2023Article
- Biochemical Characterization and Functional Analysis of Glucose Regulated Protein 78 from the SilkwormInternational journal of molecular sciences · 2023Article
- iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers.Cell death and differentiation · 2023Article
- Characterization, Stress Response and Functional Analyses of Giant River Prawn (Animals : an open access journal from MDPI · 2021Article
- The Epstein-Barr Virus Lytic Protein BMLF1 Induces Upregulation of GRP78 Expression through ATF6 Activation.International journal of molecular sciences · 2021Article
- Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage.Molecular cell · 2020Article
- Endoplasmic reticulum stress confers 5-fluorouracil resistance in breast cancer cellAmerican journal of cancer research · 2020Article
- Suberoylanilide hydroxamic acid upregulates histone acetylation and activates endoplasmic reticulum stress to induce apoptosis in HepG2 liver cancer cells.Oncology letters · 2019Article
- Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions.PLoS genetics · 2018Article
- Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop.Scientific reports · 2016Article
- Identification and characterization of two novel spliced genes located in the orf47-orf46-orf45 gene locus of Kaposi's sarcoma-associated herpesvirus.Journal of virology · 2014Article
- GRP78 is a novel receptor initiating a vascular barrier protective response to oxidized phospholipids.Molecular biology of the cell · 2014Article
- Article
- O-GlcNAcylation regulates EZH2 protein stability and function.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Transcriptome analysis of the initial stage of acute WSSV infection caused by temperature change.PloS one · 2014Article
- Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucose-regulated protein 78 (GRP78), a key regulator of endoplasmic reticulum (ER) stress, facilitates cancer cell growth and viral replication. The mechanism leading to grp78 gene activation during viral infection is largely unknown. In this study, we show that the immediate-early 1 (IE1-72) protein of the human cytomegalovirus (HCMV) is essential for HCMV-mediated GRP78 activation. IE1-72 upregulated grp78 gene expression depending on the ATP-binding site, the zinc-finger domain and the putative leucine-zipper motif of IE1-72, as well as the ER stress response elements (ERSEs) on the grp78 promoter. The purified IE1-72 protein bound to the CCAAT box within ERSE in vitro, whereas deletion mutants of IE1-72 deficient in grp78 promoter stimulation failed to do so. Moreover, IE1-72 binding to the grp78 promoter in infected cells accompanied the recruitment of TATA box-binding protein-associated factor 1 (TAF1), a histone acetyltransferase, and the increased level of acetylated histone H4, an indicator of active-state chromatin. These results provide evidence that HCMV IE1-72 activates grp78 gene expression through direct promoter binding and modulation of the local chromatin structure, indicating an active viral mechanism of cellular chaperone induction for viral growth.
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