ArticleMolecular biology and evolution2011
Ecologically and evolutionarily important SNPs identified in natural populations.
Article in Molecular biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A pangenome framework uncovers the role of deletions in repeated evolution of cave-derived traits.Genome research · 2026Article
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- Independently evolved pollution resistance in four killifish populations is largely explained by few variants of large effect.Evolutionary applications · 2024Article
- Evidence of micro-evolution in Crocidura russula from two abandoned heavy metal mines: potential use of Cytb, CYP1A1, and p53 as gene biomarkers.Ecotoxicology (London, England) · 2021Article
- Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor.Nature biomedical engineering · 2021Article
- Interindividual plasticity in metabolic and thermal tolerance traits from populations subjected to recent anthropogenic heating.Royal Society open science · 2021Article
- The chemical defensome of five model teleost fish.Scientific reports · 2021Article
- Polygenic Selection within a Single Generation Leads to Subtle Divergence among Ecological NichesINc.Genome biology and evolution · 2021Article
- Temporal changes in gene expression and genotype frequency of the ornithine decarboxylase gene in native silversideEvolutionary applications · 2020Article
- Population-level inferences from environmental DNA-Current status and future perspectives.Evolutionary applications · 2020Review
- Effects of marker type and filtering criteria onRoyal Society open science · 2019Article
- Genome-wide scan reveals signatures of selection related to pollution adaptation in non-model estuarine Atlantic killifish (Fundulus heteroclitus).Aquatic toxicology (Amsterdam, Netherlands) · 2018Article
- Stable genetic structure and connectivity in pollution-adapted and nearby pollution-sensitive populations ofRoyal Society open science · 2018Article
- When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Evolutionary applications · 2017Review
- Divergent functional isoforms drive niche specialisation for nutrient acquisition and use in rumen microbiome.The ISME journal · 2017Article
- Adaptive capabilities and fitness consequences associated with pollution exposure in fish.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Article
- Article
- Targeted approach to identify genetic loci associated with evolved dioxin tolerance in Atlantic killifish (Fundulus heteroclitus).BMC evolutionary biology · 2014Article
- Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes found despite striking morphological differences.BMC genomics · 2013Article
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2 authors.
Funding
Abstract
Evolution by natural selection acts on natural populations amidst migration, gene-by-environmental interactions, constraints, and tradeoffs, which affect the rate and frequency of adaptive change. We asked how many and how rapidly loci change in populations subject to severe, recent environmental changes. To address these questions, we used genomic approaches to identify randomly selected single nucleotide polymorphisms (SNPs) with evolutionarily significant patterns in three natural populations of Fundulus heteroclitus that inhabit and have adapted to highly polluted Superfund sites. Three statistical tests identified 1.4-2.5% of SNPs that were significantly different from the neutral model in each polluted population. These nonneutral patterns in populations adapted to highly polluted environments suggest that these loci or closely linked loci are evolving by natural selection. One SNP identified in all polluted populations using all tests is in the gene for the xenobiotic metabolizing enzyme, cytochrome P4501A (CYP1A), which has been identified previously as being refractory to induction in the three highly polluted populations. Extrapolating across the genome, these data suggest that rapid evolutionary change in natural populations can involve hundreds of loci, a few of which will be shared in independent events.
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