Evidence map›Paper›PMID 21220523›Full record

ArticleThe Journal of medicine and philosophy2011

Understanding and harnessing placebo effects: clearing away the underbrush.

Franklin G Miller, Howard Brody

Abstract read
In one paragraph

Article in The Journal of medicine and philosophy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. On Drugs.The Journal of medicine and philosophy · 2023
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. The Placebo Phenomenon: A Narrow Focus on Psychological Models.Perspectives in biology and medicine · 2018
    Article
  9. A gentle ethical defence of homeopathy.Journal of bioethical inquiry · 2015
    Article
  10. Article
  11. Article
  12. Harnessing the placebo effect: the need for translational research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Franklin G MillerDepartment of Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892, USA. fmiller@nih.gov
Howard Brody

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite strong growth in scientific investigation of the placebo effect, understanding of this phenomenon remains deeply confused. We investigate critically seven common conceptual distinctions that impede clear understanding of the placebo effect: (1) verum/placebo, (2) active/inactive, (3) signal/noise, (4) specific/nonspecific, (5) objective/subjective, (6) disease/illness, and (7) intervention/context. We argue that some of these should be eliminated entirely, whereas others must be used with caution to avoid bias. Clearing away the conceptual underbrush is needed to lay down a path to understanding and harnessing placebo effects in clinical medicine.

Indexed as

Placebo EffectClinical Trials as TopicHumansTreatment Outcome

Identifiers

PMID21220523
PMCPMC3916752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.