ArticleThe Journal of pharmacology and experimental therapeutics2011
Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus.
Article in The Journal of pharmacology and experimental therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents - systematic review and meta-analysis.Pharmacological reports : PR · 2022Pooled it
- Adult hippocampal neurogenesis: New avenues for treatment of brain disorders.Stem cell reports · 2025Review
- Adult hippocampal neurogenesis is not necessary for the response to lithium in the forced swim test.Neuroscience letters · 2019Article
- The observed alteration in BCL2 expression following lithium treatment is influenced by the choice of normalization method.Scientific reports · 2018Article
- Vagal Nerve Stimulation for Treatment-Resistant Depression.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Paliperidone Protects SH-SY5Y Cells Against MK-801-Induced Neuronal Damage Through Inhibition of Ca(2+) Influx and Regulation of SIRT1/miR-134 Signal Pathway.Molecular neurobiology · 2016Article
- Current Neurogenic and Neuroprotective Strategies to Prevent and Treat Neurodegenerative and Neuropsychiatric Disorders.Neuromolecular medicine · 2015Review
- Synergistic and additive effects of enriched environment and lithium on the generation of new cells in adult mouse hippocampus.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- The mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis.PloS one · 2014Article
- Plastic changes in the spinal cord in motor neuron disease.BioMed research international · 2014Article
- Bridging animal and human models of exercise-induced brain plasticity.Trends in cognitive sciences · 2013Review
- The ups and downs of bipolar disorder research.Biological psychiatry · 2013Article
- Neural plasticity and proliferation in the generation of antidepressant effects: hippocampal implication.Neural plasticity · 2013Review
- Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice.Behavioural brain research · 2012Article
- Stem cells in drug screening for neurodegenerative disease.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2012Article
- GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder.Frontiers in molecular neuroscience · 2012Article
- Depression, antidepressants, and neurogenesis: a critical reappraisal.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Review
- Several stressors fail to reduce adult hippocampal neurogenesis.Psychoneuroendocrinology · 2011Article
- The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression.CNS drugs · 2011Review
- Synapsin III: role in neuronal plasticity and disease.Seminars in cell & developmental biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Several antidepressant drugs have previously been reported to increase neurogenesis in the dentate gyrus of the hippocampus in laboratory animals. We found no effect of the selective serotonin reuptake inhibitor fluoxetine or the corticotropin-releasing factor receptor 1 antagonist R121919 [3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N,N-dipropyl-1H-pyrazolo[1,5-a]pyrimidin-8-ium-7-amine] on the rate of cell proliferation or hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression in either adult or adolescent rats after long-term administration. In adults, the mood stabilizer lithium was found to significantly increase cell proliferation; the atypical antipsychotic paliperidone did not affect proliferation, either alone or when combined with lithium. Fourteen-day survival of neuronally fated cells showed a significant interaction effect of lithium and paliperidone but no effect of either drug alone. BDNF mRNA expression was significantly decreased by lithium in the CA1/2 cell fields and increased by paliperidone in the CA1/2, CA3, and dentate gyrus. These results raise questions concerning the hypothesis that all antidepressants increase neurogenesis under nonstressed conditions. They also confirm and extend previous reports of lithium-induced increases in cell proliferation but not survival.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.