ReviewJournal of dental research2011
Limitations in bonding to dentin and experimental strategies to prevent bond degradation.
Review in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 203 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
203 citing papers in PubMed, 1 synthesis or guideline pooled it, 652 citations in OpenAlex.
- Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies.Odontology · 2025Pooled it
- Clinical performance of the ethanol-wet bonding technique with different adhesive systems in noncarious cervical lesion restorations: a 6-year randomized clinical trial.Clinical oral investigations · 2026Trial
- Immediate human pulp response to ethanol-wet bonding technique.Journal of dentistry · 2015Trial
- The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for remineralization of artificial caries-like dentin.Dental materials : official publication of the Academy of Dental Materials · 2011Trial
- Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.Clinical and experimental dental research · 2026Article
- In situ formation of Ca-Ag hybrid nanoparticles for multifunctional reconstruction of the resin-dentin interface.Clinical oral investigations · 2026Article
- The Use of Bovine Teeth as an Experimental Substrate in the Evaluation of Shear in Contemporary Adhesive Systems.Polymers · 2026Article
- Effects of phytic and tannic acids on dentin bonding, nanoleakage, and micropermeability under wet and dry bonding techniques.Odontology · 2026Article
- Biomimetic strategies for the dentin mineralization, using bioactive molecules: a scoping review and bibliometric analysis (2015-2025).Odontology · 2026Review
- Physicochemical and remineralisation properties of calcium silicate and glass ionomer cements applied in simulated caries-affected dentine.European journal of oral sciences · 2026Article
- Development of multifunctional dental adhesive with 4-formylphenyl acrylate and nano-silver.Clinical oral investigations · 2026Article
- Partial Ceramic Veneers as a Conservative Restorative Strategy: A Narrative Review with Case Report.Dentistry journal · 2026Review
- The contribution of different types of polyphenols to bonding performance by enhancing the stabilization of the hybrid layer.Clinical oral investigations · 2026Article
- Bonding Performance and Interfacial Ultra-Morphology/Nanoleakage of a Modern Self-Curing Bulk-Fill Restorative System: An In Vitro Study.European journal of dentistry · 2026Article
- Evaluation of bioactive glass primer on dentin bonding durability and interface properties.BMC oral health · 2025Article
- Marginal integrity produced by quaternary ammonium methacrylate-based dental adhesive tested under physiologically relevant models.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Investigation of Stress Distribution and Fatigue Performance in Restored Teeth Using Different Thicknesses of Adhesive Materials and Different Restorative Materials: 3D Finite Element Analysis (FEM).Materials (Basel, Switzerland) · 2025Article
- Effects of crosslinker-modified etchants on durability of resin-dentin bonds in sound and caries-affected dentin.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Phosphoric Acid Modified With Polyphenol-Rich Plant Extracts: Bond Strength to Sound and Eroded Dentin.The journal of adhesive dentistry · 2025Article
- Advances in macro-bioactive materials enhancing dentin bonding.Discover nano · 2025Review
143 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 4 countries.
Funding
Abstract
The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-colored restorations. Bond degradation occurs via hydrolysis of suboptimally polymerized hydrophilic resin components and degradation of water-rich, resin-sparse collagen matrices by matrix metalloproteinases (MMPs) and cysteine cathepsins. This review examined data generated over the past three years on five experimental strategies developed by different research groups for extending the longevity of resin-dentin bonds. They include: (1) increasing the degree of conversion and esterase resistance of hydrophilic adhesives; (2) the use of broad-spectrum inhibitors of collagenolytic enzymes, including novel inhibitor functional groups grafted to methacrylate resins monomers to produce anti-MMP adhesives; (3) the use of cross-linking agents for silencing the activities of MMP and cathepsins that irreversibly alter the 3-D structures of their catalytic/allosteric domains; (4) ethanol wet-bonding with hydrophobic resins to completely replace water from the extrafibrillar and intrafibrillar collagen compartments and immobilize the collagenolytic enzymes; and (5) biomimetic remineralization of the water-filled collagen matrix using analogs of matrix proteins to progressively replace water with intrafibrillar and extrafibrillar apatites to exclude exogenous collagenolytic enzymes and fossilize endogenous collagenolytic enzymes. A combination of several of these strategies should result in overcoming the critical barriers to progress currently encountered in dentin bonding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.