SynthesisArchives of disease in childhood2011
What clinical signs best identify severe illness in young infants aged 0-59 days in developing countries? A systematic review.
Synthesis in Archives of disease in childhood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Diagnostic accuracy of tachypnoea for predicting mortality and identifying sepsis in young infants aged 0-59 days: a systematic review and meta-analysis.BMJ paediatrics open · 2026Pooled it
- Clinical Signs Associated With Mortality and Sepsis in Young Infants: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2026Pooled it
- Pooled it
- The ability of non-physician health workers to identify chest indrawing to detect pneumonia in children below five years of age in low- and middle-income countries: A systematic review and meta-analysis.Journal of global health · 2023Pooled it
- Guideline
- Article
- Venous-significant intracranial hemorrhage in neonatal HIE treated with therapeutic hypothermia: imaging phenotypes, diagnostic pitfalls, and prognostic implications.Frontiers in neuroscience · 2026Review
- Maternal awareness of newborn danger signs before discharge: a secondary analysis of baseline data from a quasi-experimental study in Uganda.Maternal health, neonatology and perinatology · 2025Article
- Article
- Association of clinical signs of possible serious bacterial infections identified by community health workers with mortality of young infants in South Asia: a prospective, observational cohort study.EClinicalMedicine · 2025Article
- Hypoxaemia and risk of death among children: rethinking oxygen saturation, risk-stratification, and the role of pulse oximetry in primary care.The Lancet. Global health · 2024Review
- Prevalence and determinants of early onset neonatal sepsis at two selected public referral hospitals in the Northwest Ethiopia: a cross-sectional study.BMC pediatrics · 2023Article
- World Health Organization Danger Signs to predict bacterial sepsis in young infants: A pragmatic cohort study.PLOS global public health · 2023Article
- External validation of inpatient neonatal mortality prediction models in high-mortality settings.BMC medicine · 2022Article
- Readiness of the Kenyan public health sector to provide pre-referral care for severe paediatric malaria.Tropical medicine & international health : TM & IH · 2022Article
- Article
- [Paediatric Life Support].Notfall & rettungsmedizin · 2021Review
- Feasibility of a Mobile Health Tool for Mothers to Identify Neonatal Illness in Rural Uganda: Acceptability Study.JMIR mHealth and uHealth · 2020Article
- Predictors of Neonatal Sepsis in Hospitals at Wolaita Sodo Town, Southern Ethiopia: Institution-Based Unmatched Case-Control Study, 2019.International journal of pediatrics · 2020Article
- Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study.PloS one · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Despite recent overall improvement in the survival of under-five children worldwide, mortality among young infants remains high, and accounts for an increasing proportion of child deaths in resource-poor settings. In such settings, clinical decisions for appropriate management of severely ill infants have to be made on the basis of presenting clinical signs, and with limited or no laboratory facilities. This review summarises the evidence from observational studies of clinical signs of severe illnesses in young infants aged 0-59 days, with a particular focus on defining a minimum set of best predictors of the need for hospital-level care. Available moderate to high quality evidence suggests that, among sick infants aged 0-59 days brought to a health facility, the following clinical signs-alone or in combination-are likely to be the most valuable in identifying infants at risk of severe illness warranting hospital-level care: history of feeding difficulty, history of convulsions, temperature (axillary) ≥37.5°C or <35.5°C, change in level of activity, fast breathing/respiratory rate ≥60 breaths per minute, severe chest indrawing, grunting and cyanosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.