ReviewEnvironmental health perspectives2011
Evaluation of the cardiovascular effects of methylmercury exposures: current evidence supports development of a dose-response function for regulatory benefits analysis.
Review in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 7 syntheses or guidelines pooled it, 256 citations in OpenAlex.
- Re-thinking the link between exposure to mercury and blood pressure.Archives of toxicology · 2025Pooled it
- A review of health and wellness studies involving Inuit of Manitoba and Nunavut.International journal of circumpolar health · 2020Pooled it
- Chronic mercury exposure and blood pressure in children and adolescents: a systematic review.Environmental science and pollution research international · 2019Pooled it
- Mercury Exposure, Blood Pressure, and Hypertension: A Systematic Review and Dose-response Meta-analysis.Environmental health perspectives · 2018Pooled it
- Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review Beyond Lead and Cadmium.Current environmental health reports · 2016Pooled it
- Mercury Exposure and Heart Rate Variability: a Systematic Review.Current environmental health reports · 2015Pooled it
- Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review.Bulletin of the World Health Organization · 2014Pooled it
- Impact of environmental heavy metal exposure on cardiovascular disease mortality.American journal of preventive cardiology · 2026Article
- Heavy Metal Toxicity in Clinical and Environmental Health: Sources, Mechanisms, Diagnostics, and Evidence-Based Management of Mercury, Lead, Cadmium, and Arsenic.International journal of molecular sciences · 2026Review
- Article
- Global mercury dataset with predicted methylmercury concentrations in seafoods during 1995-2022.Scientific data · 2025Article
- China's municipal wastewater policies enhanced seafood safety and offset health risks from atmospheric mercury emissions in the past four decades.Nature food · 2025Article
- Regional variation in fish mercury.Nature food · 2024Article
- Tree Rings Mercury Controlled by Atmospheric Gaseous Elemental Mercury and Tree Physiology.Environmental science & technology · 2024Article
- Anthropogenic short-lived halogens increase human exposure to mercury contamination due to enhanced mercury oxidation over continents.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Review
- Addressing the Missing Links in Cardiovascular Aging.Clinical interventions in aging · 2024Review
- A high spatial resolution dataset for methylmercury exposure in Guangdong-Hong Kong-Macao Greater Bay Area.Scientific data · 2023Article
- Sociodemographic Disparities in Mercury Exposure from United States Coal-Fired Power Plants.Environmental science & technology letters · 2023Article
- Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 5 countries.
Funding
Abstract
backgroundThe U.S. Environmental Protection Agency (U.S. EPA) has estimated the neurological benefits of reductions in prenatal methylmercury (MeHg) exposure in past assessments of rules controlling mercury (Hg) emissions. A growing body of evidence suggests that MeHg exposure can also lead to increased risks of adverse cardiovascular impacts in exposed populations. DATA EXTRACTION: The U.S. EPA assembled the authors of this article to participate in a workshop, where we reviewed the current science concerning cardiovascular health effects of MeHg exposure via fish and seafood consumption and provided recommendations concerning whether cardiovascular health effects should be included in future Hg regulatory impact analyses. DATA SYNTHESIS: We found the body of evidence exploring the link between MeHg and acute myocardial infarction (MI) to be sufficiently strong to support its inclusion in future benefits analyses, based both on direct epidemiological evidence of an MeHg-MI link and on MeHg's association with intermediary impacts that contribute to MI risk. Although additional research in this area would be beneficial to further clarify key characteristics of this relationship and the biological mechanisms that underlie it, we consider the current epidemiological literature sufficiently robust to support the development of a dose- response function.
conclusionsWe recommend the development of a dose- response function relating MeHg exposures with MIs for use in regulatory benefits analyses of future rules targeting Hg air emissions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.