Routine probiotics for premature infants: let's be careful!

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

1. Bifidobacterium and Lactobacillus for preventing necrotizing enterocolitis in very-low-birth-weight preterm infants: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2020
   Pooled it
2. Effects of probiotics on experimental necrotizing enterocolitis: a systematic review and meta-analysis.Pediatric research · 2018
   Pooled it
3. Probiotic supplementation in preterm infants does not affect the risk of retinopathy of prematurity: a meta-analysis of randomized controlled trials.Scientific reports · 2017
   Pooled it
4. A comparison of two probiotic strains of bifidobacteria in premature infants.The Journal of pediatrics · 2013
   Trial
5. Frontiers in cellular and infection microbiology · 2022
   Article
6. Probiotics for preterm infants: A National Retrospective Cohort Study.Journal of perinatology : official journal of the California Perinatal Association · 2019
   Article
7. Colonization of preterm gnotobiotic piglets with probiotic Lactobacillus rhamnosus GG and its interference with Salmonella Typhimurium.Clinical and experimental immunology · 2019
   Article
8. Strategies for the Preservation, Restoration and Modulation of the Human Milk Microbiota. Implications for Human Milk Banks and Neonatal Intensive Care Units.Frontiers in microbiology · 2018
   Review
9. Probiotics and necrotizing enterocolitis.Clinics in perinatology · 2014
   Review
10. Effect of routine probiotic, Lactobacillus reuteri DSM 17938, use on rates of necrotizing enterocolitis in neonates with birthweight < 1000 grams: a sequential analysis.BMC pediatrics · 2012
    Article
11. Probiotics to improve the gut microbiome in premature infants: are we there yet?Gut microbes
    Review
12. Translating neonatal microbiome science into commercial innovation: metabolism of human milk oligosaccharides as a basis for probiotic efficacy in breast-fed infants.Gut microbes
    Review

Corrections and comments

• Commented on by
  To NEC or not to NEC: routine use of probiotics for premature infants.2011

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as