ArticleNeuron2011
Functional architecture of olfactory ionotropic glutamate receptors.
Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 336 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
336 citing papers in PubMed, 608 citations in OpenAlex.
- Identification of markers facilitating the study of support cells in adult olfactory sensilla in Drosophila.Insect biochemistry and molecular biology · 2026Article
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- Functional conservation of IR75q.2 in the recognition of volatile acids and aldehydes in two Spodoptera species.Crop health · 2026Article
- Antennal transcriptome analysis and expression profiling of odorant binding proteins and odorant receptors in the teak defoliator, Hyblaea puera (Lepidoptera: Hyblaeidae).BMC genomics · 2026Article
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- Genome-Wide Identification and Characterization of Chemosensory Gene Families in the MayflyGenes · 2026Article
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- IR25a-like Receptors are Required for Olfactory Detection of Plant Volatiles in the Carmine Spider Mite.Journal of chemical ecology · 2026Article
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- Genome-Wide Characterization of Four Gastropod Species Ionotropic Receptors Reveals Diet-Linked Evolutionary Patterns of Functional Divergence.Animals : an open access journal from MDPI · 2026Article
- The sensory gene repertoire of deep-sea hydrothermal shrimp.PloS one · 2026Article
- Comparative Expression Analysis of Olfactory Receptor Genes Among Individuals With Soldier and Worker Caste Differentiation Fates in Termites.Ecology and evolution · 2025Article
- Multilayer regulation underlies the functional precision and evolutionary potential of the olfactory system.Nature communications · 2025Article
- An Orco dependent pathway suppresses egg-laying attraction to ripe fruit volatile compounds in Drosophila melanogaster but not in D. suzukii.BMC ecology and evolution · 2025Article
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- The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission.Parasites & vectors · 2025Review
- The sensory arsenal mosquitoes use to find us.Trends in parasitology · 2025Review
- Expression analyses of chemosensory genes provide insights into evolution of gustatory receptor genes in the bumble bee Bombus impatiens.BMC genomics · 2025Article
276 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
video abstractIonotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate chemical communication between neurons at synapses. A variant iGluR subfamily, the Ionotropic Receptors (IRs), was recently proposed to detect environmental volatile chemicals in olfactory cilia. Here, we elucidate how these peripheral chemosensors have evolved mechanistically from their iGluR ancestors. Using a Drosophila model, we demonstrate that IRs act in combinations of up to three subunits, comprising individual odor-specific receptors and one or two broadly expressed coreceptors. Heteromeric IR complex formation is necessary and sufficient for trafficking to cilia and mediating odor-evoked electrophysiological responses in vivo and in vitro. IRs display heterogeneous ion conduction specificities related to their variable pore sequences, and divergent ligand-binding domains function in odor recognition and cilia localization. Our results provide insights into the conserved and distinct architecture of these olfactory and synaptic ion channels and offer perspectives into the use of IRs as genetically encoded chemical sensors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.