ArticleBehavioural brain research2011
Effect of environmental enrichment on methylphenidate-induced locomotion and dopamine transporter dynamics.
Article in Behavioural brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Environmental enrichment and sex, but not n-acetylcysteine, alter extended-access amphetamine self-administration and cue-seeking.Behavioural brain research · 2025Article
- A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.Frontiers in behavioral neuroscience · 2024Article
- Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review.Pharmacology, biochemistry, and behavior · 2022Review
- The role of enriched environment in neural development and repair.Frontiers in cellular neuroscience · 2022Review
- Environmental enrichment and a selective metabotropic glutamate receptorPharmacology, biochemistry, and behavior · 2020Article
- Recovery from behavior and developmental effects of chronic oral methylphenidate following an abstinence period.Pharmacology, biochemistry, and behavior · 2018Article
- Differential housing and novelty response: Protection and risk from locomotor sensitization.Pharmacology, biochemistry, and behavior · 2017Article
- Environmental Enrichment Prevents Methamphetamine-Induced Spatial Memory Deficits and Obsessive-Compulsive Behavior in Rats.Iranian journal of psychiatry · 2017Article
- Environmental enrichment enhances synaptic plasticity by internalization of striatal dopamine transporters.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Environmental condition alters amphetamine self-administration: role of the MGluR₅ receptor and schedule of reinforcement.Psychopharmacology · 2015Article
- Prefrontal microRNA-221 Mediates Environmental Enrichment-Induced Increase of Locomotor Sensitivity to Nicotine.The international journal of neuropsychopharmacology · 2015Article
- Effects of environmental enrichment on ERK1/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration.The European journal of neuroscience · 2015Article
- The effects of mGluR2/3 activation on acute and repeated amphetamine-induced locomotor activity in differentially reared male rats.Experimental and clinical psychopharmacology · 2014Article
- Environmental rearing effects on impulsivity and reward sensitivity.Behavioral neuroscience · 2013Article
- The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats.Brain research · 2013Article
- Distinct effects of enriched environment on dopamine clearance in nucleus accumbens shell and core following systemic nicotine administration.Synapse (New York, N.Y.) · 2013Article
- Individual differences and social influences on the neurobehavioral pharmacology of abused drugs.Pharmacological reviews · 2013Review
- Isolation rearing as a preclinical model of attention/deficit-hyperactivity disorder.Behavioural brain research · 2012Article
- Environmental enrichment during development decreases intravenous self-administration of methylphenidate at low unit doses in rats.Behavioural pharmacology · 2012Article
- Impact of mGluR5 during amphetamine-induced hyperactivity and conditioned hyperactivity in differentially reared rats.Psychopharmacology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Rats raised in an enriched condition (EC) are less sensitive to the locomotor effects of stimulant drugs than rats raised in an impoverished condition (IC). Methylphenidate (MPD), a primary pharmacotherapy for attention-deficit/hyperactivity disorder, has abuse potential. This study determined whether environmental enrichment differentially altered the effects of MPD on locomotor activity and dopamine (DA) transporter (DAT) function. Acute and repeated MPD (3 or 10 mg/kg, s.c.) increased locomotion in EC, IC and social condition (SC) rats; however, EC rats showed a blunted response to repeated MPD (3 mg/kg). The maximal velocity (V(max)) of [(3)H]DA uptake in the presence of the combination of phorbol 12-myristate 13-acetate, a protein kinase C (PKC) activator and okadaic acid, a protein phosphatase inhibitor was decreased in EC and IC rats by 68% and 40%, respectively, indicating that DAT in prefrontal cortex (PFC) is more sensitive to PKC-mediated down-regulation in EC rats. Acute MPD (10 mg/kg) administration decreased the V(max) of [(3)H]DA uptake in PFC and striatum in EC rats, but not in IC rats. Furthermore, [(3)H]WIN 35,428 binding density was decreased in PFC of EC and IC rats, and in striatum of EC rats given repeated MPD (10 mg/kg). These results demonstrate that environmental enrichment modulates DAT dynamics in PFC. However, since the change in DAT function was observed only following the high dose of MPH (10 mg/kg), the attenuated locomotor response to repeated MPD (3 mg/kg) in EC rats is not likely due to a specific DAT alteration in the brain regions examined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.