ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2011
Missed opportunities for tuberculosis diagnosis.
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Effect of integrating traditional and modern healthcare systems on tuberculosis case detection in Ethiopia: a cluster randomized controlled study.Infectious diseases of poverty · 2025Trial
- MPT64 patch test for the diagnosis of active pulmonary tuberculosis: a randomised controlled trial in Peru.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018Trial
- Longitudinal Symptom Transitions Predict Incident Tuberculosis Risk in Serial Active Case Finding.The Journal of infectious diseases · 2026Article
- "That is why I trust": a qualitative study on acceptability and feasibility of novel tongue swab diagnostics to assess people presenting with tuberculosis symptoms in Viet Nam and Zambia.BMC health services research · 2026Article
- Longitudinal symptom transitions predict incident tuberculosis risk among persons deprived of liberty in Brazil.medRxiv : the preprint server for health sciences · 2025Article
- Missed opportunities for diagnosis and treatment in patients with TB symptoms: a systematic review.Public health action · 2022Review
- Variation of tuberculosis prevalence across diagnostic approaches and geographical areas of Indonesia.PloS one · 2021Article
- Active TB case finding in a high burden setting; comparison of community and facility-based strategies in Lusaka, Zambia.PloS one · 2020Article
- TB in Vulnerable Populations: The Case of an Indigenous Community in the Peruvian Amazon.Health and human rights · 2016Article
- Screening of the antimycobacterial activity of novel lipophilic agents by the modified broth based method.Journal of clinical tuberculosis and other mycobacterial diseases · 2016Article
- Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides.Nucleic acids research · 2015Article
- Yield of undetected tuberculosis and human immunodeficiency virus coinfection from active case finding in urban Uganda.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2014Article
- Comparison of gene expression profiles between pansensitive and multidrug-resistant strains of Mycobacterium tuberculosis.Current microbiology · 2013Article
- Article
- Loss to follow up during diagnosis of presumptive pulmonary tuberculosis at a tertiary care hospital.Journal of family medicine and primary careArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn high tuberculosis (TB) burden, resource-poor countries, sputum smear microscopy remains the mainstay of diagnosis. The low sensitivity of this test means that patients with smear-negative but culture-positive TB pass undetected through the health care system. Such clinical episodes are missed opportunities for diagnosis and interruption of transmission, which might be averted through the application of more sensitive diagnostic tests.
objectivesTo estimate the proportion of incident TB cases that might have been detected earlier than the actual date of diagnosis if a test more sensitive than smear microscopy had been used at an earlier presentation episode.
methodRetrospective cohort study in urban Peru, investigating health care facility interactions for symptoms suggestive of TB prior to TB diagnosis through patient interviews and a review of clinical records.
resultsOf 212 participants enrolled, 58% had one or more clinical interactions prior to their diagnostic episode. Of those with a prior episode, the median number of episodes was three. The median delay to diagnosis from first presentation was 26 days.
conclusionThere are clear missed opportunities for earlier TB diagnosis, delaying treatment initiation and continued spread of Mycobacterium tuberculosis to the community. The implementation of sensitive diagnostic tests appropriate to resource-poor settings should be given high priority.
Indexed as
Identifiers
21219682PMC3104290W2099410387What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.