ArticleThe Plant journal : for cell and molecular biology2011
Multiple light inputs to a simple clock circuit allow complex biological rhythms.
Article in The Plant journal : for cell and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- Abundant clock proteins point to missing molecular regulation in the plant circadian clock.Molecular systems biology · 2025Article
- The Circadian Clock Coordinates the Tradeoff between Adaptation to Abiotic Stresses and Yield in Crops.Biology · 2023Review
- A phospho-dawn of protein modification anticipates light onset in the picoeukaryote Ostreococcus tauri.Journal of experimental botany · 2023Article
- Deep-coverage spatiotemporal proteome of the picoeukaryote Ostreococcus tauri reveals differential effects of environmental and endogenous 24-hour rhythms.Communications biology · 2021Article
- Nyctinastic thallus movement in the liverwort Marchantia polymorpha is regulated by a circadian clock.Scientific reports · 2020Article
- Article
- Expanding the bioluminescent reporter toolkit for plant science with NanoLUC.Plant methods · 2019Article
- Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes.Genome biology and evolution · 2019Article
- Early evolution of the land plant circadian clock.The New phytologist · 2017Article
- Mistletoe Berry Outline Mapping with a Path Curve Function and Recording the Circadian Rhythm of Their Phenotypic Shape Change.Frontiers in plant science · 2016Article
- A Compact Model for the Complex Plant Circadian Clock.Frontiers in plant science · 2016Article
- Bridging the gap between omics and earth system science to better understand how environmental change impacts marine microbes.Global change biology · 2016Review
- Label-free quantitative analysis of the casein kinase 2-responsive phosphoproteome of the marine minimal model species Ostreococcus tauri.Proteomics · 2015Article
- Defining the robust behaviour of the plant clock gene circuit with absolute RNA timeseries and open infrastructure.Open biology · 2015Article
- Circadian systems biology: When time matters.Computational and structural biotechnology journal · 2015Review
- Probing entrainment of Ostreococcus tauri circadian clock by green and blue light through a mathematical modeling approach.Frontiers in genetics · 2015Article
- The reduced kinome of Ostreococcus tauri: core eukaryotic signalling components in a tractable model species.BMC genomics · 2014Article
- Light and circadian regulation of clock components aids flexible responses to environmental signals.The New phytologist · 2014Article
- Stochastic models of cellular circadian rhythms in plants help to understand the impact of noise on robustness and clock structure.Frontiers in plant science · 2014Article
- Heat shock-induced fluctuations in clock and light signaling enhance phytochrome B-mediated Arabidopsis deetiolation.The Plant cell · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Circadian clocks are biological timekeepers that allow living cells to time their activity in anticipation of predictable environmental changes. Detailed understanding of the circadian network of higher plants, such as Arabidopsis thaliana, is hampered by the high number of partially redundant genes. However, the picoeukaryotic alga Ostreococcus tauri, which was recently shown to possess a small number of non-redundant clock genes, presents an attractive alternative target for detailed modelling of circadian clocks in the green lineage. Based on extensive time-series data from in vivo reporter gene assays, we developed a model of the Ostreococcus clock as a feedback loop between the genes TOC1 and CCA1. The model reproduces the dynamics of the transcriptional and translational reporters over a range of photoperiods. Surprisingly, the model is also able to predict the transient behaviour of the clock when the light conditions are altered. Despite the apparent simplicity of the clock circuit, it displays considerable complexity in its response to changing light conditions. Systematic screening of the effects of altered day length revealed a complex relationship between phase and photoperiod, which is also captured by the model. The complex light response is shown to stem from circadian gating of light-dependent mechanisms. This study provides insights into the contributions of light inputs to the Ostreococcus clock. The model suggests that a high number of light-dependent reactions are important for flexible timing in a circadian clock with only one feedback loop.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.