ArticleMolecular microbiology2011
Characterization of Helicobacter pylori factors that control transformation frequency and integration length during inter-strain DNA recombination.
Article in Molecular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Improved DNA binding to a type IV minor pilin increases natural transformation.Nucleic acids research · 2025Article
- Intragenomic conflicts with plasmids and chromosomal mobile genetic elements drive the evolution of natural transformation within species.PLoS biology · 2024Article
- Article
- DNA binding is rate-limiting for natural transformation.bioRxiv : the preprint server for biology · 2024Article
- Horizontal gene transfer facilitates the molecular reverse-evolution of antibiotic sensitivity in experimental populations of H. pylori.Nature ecology & evolution · 2024Article
- Base-excision restriction enzymes: expanding the world of epigenetic immune systems.DNA research : an international journal for rapid publication of reports on genes and genomes · 2023Article
- Article
- The molecular diversity of transcriptional factor TfoX is a determinant in natural transformation inFrontiers in microbiology · 2022Article
- Genetic Markers of Genome Rearrangements inMicroorganisms · 2021Article
- Excision and transfer of an integrating and conjugative element in a bacterial species with high recombination efficiency.Scientific reports · 2019Article
- N4-cytosine DNA methylation regulates transcription and pathogenesis in Helicobacter pylori.Nucleic acids research · 2018Article
- Basic Characterization of Natural Transformation in a Highly TransformableFrontiers in cellular and infection microbiology · 2018Article
- Methylation-dependent DNA discrimination in natural transformation ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- DprA from Neisseria meningitidis: properties and role in natural competence for transformation.Microbiology (Reading, England) · 2017Article
- Structural basis for the substrate selectivity of Helicobacter pylori NucT nuclease activity.PloS one · 2017Article
- Natural Competence Is Common among Clinical Isolates ofFrontiers in cellular and infection microbiology · 2017Article
- Natural Competence of Xylella fastidiosa Occurs at a High Frequency Inside Microfluidic Chambers Mimicking the Bacterium's Natural Habitats.Applied and environmental microbiology · 2016Article
- Serum Albumin and Ca2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2016Article
- Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori.Nature communications · 2016Article
- Addiction of Hypertransformable Pneumococcal Isolates to Natural Transformation for In Vivo Fitness and Virulence.Infection and immunity · 2016Article
Corrections and comments
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3 authors.
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Abstract
Helicobacter pylori is a genetically diverse bacterial species, owing in part to its natural competence for DNA uptake that facilitates recombination between strains. Inter-strain DNA recombination occurs during human infection and the H. pylori genome is in linkage equilibrium worldwide. Despite this high propensity for DNA exchange, little is known about the factors that limit the extent of recombination during natural transformation. Here, we identify restriction-modification (R-M) systems as a barrier to transformation with homeologous DNA and find that R-M systems and several components of the recombination machinery control integration length. Type II R-M systems, the nuclease nucT and resolvase ruvC reduced integration length whereas the helicase recG increased it. In addition, we characterized a new factor that promotes natural transformation in H. pylori, dprB. Although free recombination has been widely observed in H. pylori, our study suggests that this bacterium uses multiple systems to limit inter-strain recombination.
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