ArticleDiabetic medicine : a journal of the British Diabetic Association2011
Association of insulin sensitivity to lipids across the lifespan in people with Type 1 diabetes.
Article in Diabetic medicine : a journal of the British Diabetic Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Improving Assessment of Lipoprotein Profile in Type 1 Diabetes by 1H NMR Spectroscopy.PloS one · 2015Trial
- Distinct insulin sensitivity profiles revealed by clustering based on continuous glucose monitoring data in people living with type 1 diabetes.Frontiers in endocrinology · 2026Article
- Cumulative exposures to glycaemia and lipids are associated with coronary artery disease in type 1 diabetes: a call for action.Cardiovascular diabetology · 2025Article
- Insulin Resistance in Type 1 Diabetes: Pathophysiological, Clinical, and Therapeutic Relevance.Endocrine reviews · 2025Review
- Postprandial Glucose Turnover Differs Between Adolescents and Adults With Type 1 Diabetes: Triple Tracer Mixed Meal Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Investigating the Incidence of Dyslipidemia among Brazilian Children and Adolescents Diagnosed with Type 1 Diabetes Mellitus: A Cross-Sectional Study.Diseases (Basel, Switzerland) · 2024Article
- Joint 30-year HbA1c and lipid trajectories and mortality in type 1 diabetes.Diabetes research and clinical practice · 2022Article
- Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort.Diabetes care · 2022Article
- The Theory of Hyperlipidemic Memory of Type 1 Diabetes.Frontiers in endocrinology · 2022Article
- Twenty years of pediatric diabetes surveillance: what do we know and why it matters.Annals of the New York Academy of Sciences · 2021Review
- Hemoglobin A1c modifies the association between triglyceride and time in hypoglycemia determined by flash glucose monitoring in adults with type 1 diabetes: implications for individualized therapy and decision-making.Annals of translational medicine · 2021Article
- Mechanisms and early patterns of dyslipidemia in pediatric type 1 and type 2 diabetes.Journal of pediatric endocrinology & metabolism : JPEM · 2020Article
- Comparison of mechanisms and transferability of outcomes of SGLT2 inhibition between type 1 and type 2 diabetes.Endocrinology, diabetes & metabolism · 2020Review
- Leptin and HPA axis activity in diabetic rats: Effects of adrenergic agonists.Brain research · 2019Article
- Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review.Current diabetes reports · 2018Review
- Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers.Vascular medicine (London, England) · 2017Article
- Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes.Pediatric diabetes · 2016Article
- Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined.American journal of physiology. Endocrinology and metabolism · 2016Article
- Development and Validation of a Method to Estimate Insulin Sensitivity in Patients With and Without Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2016Article
- Physical activity and type 1 diabetes: time for a rewire?Journal of diabetes science and technology · 2015Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
aimsInsulin resistance and dyslipidaemia both increase cardiovascular risk in Type 1 diabetes. However, little data exist on the associations of insulin resistance to lipids in Type 1 diabetes. Our objective was to explore the associations between insulin resistance (assessed by glucose infusion rate) and lipids in people with Type 1 diabetes and determine whether adiposity and/or average glycaemia influence these associations.
methodsHyperinsulinaemic-euglycaemic clamp studies were performed in 60 subjects with Type 1 diabetes aged 12-19 years (age 15±2 years, 57% female, duration of diabetes 6.3±3.8 years, HbA(1c) 8.6±1.5%, IFCC=70 mmol/mol) and 40 subjects with Type 1 diabetes aged 27-61 years (age 45±9 years, 53% female, duration of diabetes 23±8 years, HbA(1c) 7.5±0.9%, IFCC=58 mmol/mol). Multiple linear regression models were fit to examine the association between glucose infusion rate and fasting lipid levels with adjustment for possible confounders.
resultsLower glucose infusion rate was significantly associated with lower levels of HDL cholesterol in youths with Type 1 diabetes and with higher levels of triglycerides and higher triglyceride/HDL ratio in both youths and adults. The magnitude of the associations between glucose infusion rate and lipid levels translate into interquartile differences of 0.098 mmol/l for HDL cholesterol, 0.17 mmol/l for triglycerides and 1.06 for triglycerides/HDL in the adolescents and 0.20 mmol/l for triglycerides and 1.01 for triglycerides/HDL in the adults. The associations were attenuated and no longer statistically significant by adjustment for adiposity among adults, while adjustment for HbA(1c) had a small effect in youths and adults.
conclusionsLower insulin sensitivity is associated with a more atherogenic lipid profile in both youths and adults with Type 1 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.