ArticleBritish journal of clinical pharmacology2011
Correlates of (inappropriate) benzodiazepine use: the Netherlands Study of Depression and Anxiety (NESDA).
Article in British journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risks Associated With Benzodiazepine Long-Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta-Analysis.Journal of sleep research · 2026Pooled it
- Does cognitive behavioral therapy for anxiety disorders assist the discontinuation of benzodiazepines among patients with anxiety disorders? A systematic review and meta-analysis.Psychiatry and clinical neurosciences · 2021Pooled it
- The Association Between Number of Chronic Conditions and Benzodiazepine Prescribing in Region Stockholm, Sweden: A Total Population-Based Cohort Study.Health science reports · 2026Article
- Associations between the number of benzodiazepine receptor agonists prescriptions and social determinants of health, including social capital: an ecological study.BMC public health · 2026Article
- The impact of lifetime substance use on psychiatric comorbidities and treatment seeking in patients with alcohol use disorders.Scientific reports · 2024Article
- Trends in co-prescribed opioids and benzodiazepines, non-prescribed opioids and benzodiazepines, and schedule-I drugs in the United States, 2013 to 2019.Preventive medicine reports · 2024Article
- Long-term benzodiazepine prescriptions in community psychiatry clinics.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- Hazardous use of benzodiazepine receptor agonists in psychiatric clinics in China: electronic prescription database study.BJPsych open · 2022Article
- Perception of the Regulatory Change for Zolpidem Prescription by French General Practitioners and Its Relation to Prescription Behavior.Journal of clinical medicine · 2022Article
- Article
- The influence of prescriber and patient gender on the prescription of benzodiazepines: evidence for stereotypes and biases?Social psychiatry and psychiatric epidemiology · 2021Article
- Patterns of benzodiazepine prescription among older adults in Switzerland: a cross-sectional analysis of claims data.BMJ open · 2020Article
- Comparisons Between Successful Versus Unsuccessful Switches From Benzodiazepines or Zolpidem (Z-Drug) to Controlled-Release Melatonin in Patients With Major Depressive Disorder and Insomnia.Frontiers in psychiatry · 2020Article
- Prevalence of prescribed benzodiazepine long-term use in the French general population according to sociodemographic and clinical factors: findings from the CONSTANCES cohort.BMC public health · 2019Article
- Article
- Long-term benzodiazepine use in patients taking antidepressants in a public health setting in Brazil: a cross-sectional study.BMJ open · 2018Article
- Potentially inappropriate prescriptions for elderly people taking antidepressant: comparative tools.BMC geriatrics · 2017Article
- Trends in the prescription of benzodiazepines for the elderly in Korea.BMC psychiatry · 2017Article
- Multimorbidity and use of hypnotic and anxiolytic drugs: cross-sectional and follow-up study in primary healthcare in Iceland.BMC family practice · 2016Article
- Benzodiazepine prescription for patients in treatment for drug use disorders: a nationwide cohort study in Denmark, 2000-2010.BMC psychiatry · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
aimResults on determinants of benzodiazepine (BZD) use in general and inappropriate use were inconsistent and mostly univariate. The relative importance of sociodemographic, psychological and physical determinants has never been investigated in a comprehensive, multivariate model.
methodsWe included 429 BZD users and 2423 non-users from the Netherlands Study of Depression and Anxiety (NESDA) in order to investigate sociodemographic, psychological and physical determinants of BZD use and inappropriate use by logistic and linear regression analyses.
resultsBZDs were used by a considerable proportion of the 2852 NESDA participants (15.0%). BZD use was independently associated with older age, singleness, unemployment, treatment in secondary care, higher medical consumption (more severe) anxiety, depression (OR [95% CI]=1.95 [1.29, 2.93]), comorbidity, insomnia, SSRI (OR [95% CI]=2.05 [1.55, 2.70]), TCA and other antidepressant (OR [95% CI]=2.44 [1.64, 3.62]) use. Overall, BZD use was rarely in accordance with all guidelines, mainly because most users (82.5%) exceeded the recommended duration of safe use. Inappropriate use was independently associated with older age (β=0.130) and chronic illnesses (β=0.120). Higher scores on agreeableness were associated with less inappropriate use.
conclusionsMentally or physically vulnerable subjects were most likely to use BZDs. The most vulnerable (i.e. the old and physically ill) BZD users were at highest risk of inappropriate BZD use. Without further evidence of the effectiveness of BZDs in long-term use, caution in initiating BZD prescriptions is recommended, particularly when patients are chronically ill and old, as those are most likely to display inappropriate use.
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