Evidence map›Paper›PMID 21218853›Full record

ReviewBiochemistry2011

Insights into cellular factors that regulate HIV-1 replication in human cells.

Andrew M L Lever, Kuan-Teh Jeang

Abstract readReview
In one paragraph

Review in Biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
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  3. Review
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  10. Review
  11. Article
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  18. Article
  19. MicroRNAs and human retroviruses.Biochimica et biophysica acta
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrew M L LeverAddenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, U.K.
Kuan-Teh Jeang

Funding

Molecular Mechanisms Of Human Immunodeficiency Virus Trans-regulatory ProteinsZIAAI000547 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI JEANG, KUAN-TEH · 2009 to 2013
$5.9M
Mechanisms of Cellular Transformation by HTLV-1ZIAAI001023 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI JEANG, KUAN-TEH · 2009 to 2013
$4.2M
Intramural NIH HHS Z99 AI999999Intramural NIH HHS ZIA AI001023Medical Research Council G0800142Medical Research Council G0801709
6 · The paper itself

Abstract

Retroviruses integrate into the host cell's chromosome. Accordingly, many aspects of the life cycle of retroviruses like HIV-1 are intimately linked to the functions of cellular proteins and RNAs. In this review, we discuss in brief recent genomewide screens for the identification of cellular proteins that assist HIV-1 replication in human cells. We also review findings for other cellular moieties that help or restrict the viral life cycle.

Indexed as

Chromosomes, HumanHIV-1HumansModels, BiologicalViral ProteinsVirus ReplicationViral Proteins

Identifiers

PMID21218853
PMCPMC3035746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.