ArticleBiomacromolecules2011
Bioactive stent surface coating that promotes endothelialization while preventing platelet adhesion.
Article in Biomacromolecules, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 51 citations in OpenAlex.
- Improving dental epithelial junction on dental implants with bioengineered peptides.Frontiers in bioengineering and biotechnology · 2023Article
- Development of biodegradable zein-based bilayer coatings for drug-eluting stents.RSC advances · 2021Article
- Phage Display to Augment Biomaterial Function.International journal of molecular sciences · 2020Review
- Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy.Journal of diabetes research · 2019Article
- Dopaminergic enhancement of cellular adhesion in bone marrow derived mesenchymal stem cells (MSCs).Journal of stem cell research & therapy · 2017Article
- Stability research on polydopamine and immobilized albumin on 316L stainless steel.Regenerative biomaterials · 2016Article
- Effect of a novel peptide, WKYMVm- and sirolimus-coated stent on re-endothelialization and anti-restenosis.Journal of materials science. Materials in medicine · 2015Article
- Endothelial retention and phenotype on carbonized cardiovascular implant surfaces.Biomaterials · 2014Article
- Biocompatible and bioactive surface modifications for prolonged in vivo efficacy.Chemical reviews · 2012Review
- Restenosis after PCI. Part 2: prevention and therapy.Nature reviews. Cardiology · 2011Review
- Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy.Journal of materials chemistry. BArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A bifunctional peptide coating was designed, synthesized, and evaluated as a potential pro-healing stent coating. The bifunctional peptide consisted of a short 28-mer sequence that on the N-terminus has a motif with affinity for polystyrene binding and at the C-terminus has a motif that was shown to bind selectively human endothelial cells but not platelets. Results showed that the selective coating, a polystyrene-binding peptide terminated in RRETAWA (FFSFFFPASAWGSSGSSGK(biotin)CRRETAWAC), bound endothelial cells quantitatively as well as the common RGD motif, but unlike RGD, it did not show any preference for platelet adherence. Follow-up work examining the difference in cell line selectivity between endothelial cells, whose binding should be encouraged, and smooth muscle cells, whose binding should be deprecated in a stenting application, did identify a temporal preference of the RRETAWA-terminated peptide coating for endothelial cells. However, the in vivo implications of this apparent selectivity need to be examined in more detail before definitive conclusions can be drawn. The positive in vitro results encourage the continued development of other novel coatings that mimic biological structures, signaling capabilities, or both to direct cellular processes on the surface of synthetic materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.