Evidence map›Paper›PMID 21218563›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2011

The moderating effect of the APOE [small element of] 4 allele on the relationship between hippocampal volume and cognitive decline in older depressed patients.

Natalie Sachs-Erisson, Kathryn Sawyer, Elizabeth Corsentino, Nicole Collins, David C Steffens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Neuroimaging in geriatric psychiatry: integrative research as the next frontier.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Natalie Sachs-ErissonDepartment of Psychology, Florida State University, Tallahassee, FL 32301, USA. sachs@psy.fsu.edu
Kathryn Sawyer
Elizabeth Corsentino
Nicole Collins
David C Steffens
Florida State University · USDuke Medical Center · US

Funding

Recruitment and Assessment Core Patient RecruitmentP50MH060451 · NIMH · DUKE UNIVERSITY · PI KRISHNAN, RANGA R · 2001 to 2010
$22.3M
Geriatric Depression: Risk Factors for Adverse OutcomesR01MH054846 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI STEFFENS, DAVID C. · 1995 to 2016
$10.1M
Midcareer Investigator Award in Geriatric DepressionK24MH070027 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI STEFFENS, DAVID C. · 2004 to 2013
$1.6M
Depression and Physical Functioning in Older AdultsK01MH066380 · NIMH · DUKE UNIVERSITY · PI HYBELS, CELIA F · 2003 to 2007
$533k
NIMH NIH HHS K01 MH066380NIMH NIH HHS K24 MH070027NIMH NIH HHS K24 MH70027NIMH NIH HHS P50 MH060451NIMH NIH HHS P50 MH 60451NIMH NIH HHS R01 MH054846NIMH NIH HHS R01 MH54846
6 · The paper itself

Abstract

objectivethe apolipoprotein E epsilon-4 (APOE [small element of] 4) allele and depression are independently associated with increased risk for cognitive decline (CD). The authors have reported that depressed elders with an APOE [small element of]4 allele had greater CD compared with depressed elders without the allele. Depression affects the hippocampus, and reduced hippocampal volume has been associated with CD. This study sought to examine in depressed patients the relationships between hippocampal volume, the APOE [small element of] 4 allele, and their interaction on CD. Analyses were performed to examine the influence of baseline hippocampal volume, the APOE [small element of] 4 allele, and their interactions on change in cognitive functioning overtime.

designsecondary data analysis using linear regression analyses.

settingclinical Research Center for the Study of Depression in Later Life conducted at Duke University.

participantsdepressed older patients (N = 61) followed up for 4 years. MEASURES: At baseline, cognitive functioning (assessed by the Mini-Mental State Examination), left and right hippocampal volume (assessed by magnetic resonance imaging), and APOE genotype were obtained. At 4-year follow-up, cognitive functioning was reassessed.

resultsthe APOE [small element of] 4 allele and left hippocampal volume, but not right hippocampal volume, were independently associated with CD. Importantly, the authors found the APOE [small element of]4 allele to moderate the effects of left hippocampal volume on CD. The APOE [small element of]4 allele seemed to have little effect among those with larger left hippocampal volumes, whereas the allele influenced CD among those with smaller hippocampal volumes.

conclusionfuture studies of cognitive impairment and decline should examine both individual and conjoint effects of putative risk factors.

Indexed as

AgedAged, 80 and overAllelesApolipoprotein E4AtrophyCognition DisordersDepressionFemaleFunctional LateralityGenetic Predisposition to DiseaseGenotypeHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedApolipoprotein E4

Identifiers

PMID21218563
PMCPMC3057467
OpenAlexW2066644836

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.