Evidence map›Paper›PMID 21218156›Full record

ArticleInorganica chimica acta2010

Synthesis and antimicrobial studies of silver N-heterocyclic carbene complexes bearing a methyl benzoate substituent.

Amanda R Knapp, Matthew J Panzner, Doug A Medvetz, Brian D Wright, Claire A Tessier, Wiley J Youngs

Open access · greenAbstract read
In one paragraph

Article in Inorganica chimica acta, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Amanda R KnappThe University of Akron, Akron, OH 44325-3601.
Matthew J Panzner
Doug A Medvetz
Brian D Wright
Claire A Tessier
Wiley J Youngs
University of Akron · US

Funding

Collaborative Research: Polymeric Drug Delivery Systems and Biofilms in the LungR01GM086895 · NIGMS · UNIVERSITY OF AKRON · PI YOUNG, GERALD W · 2008 to 2011
$1.5M
Silver carbene complexes as treatment of CF lung diseaseR01AI067856 · NIAID · WASHINGTON UNIVERSITY · PI CANNON, CAROLYN LOUISE · 2006 to 2008
$1.1M
NIAID NIH HHS R01 AI067856NIGMS NIH HHS R01 GM086895
6 · The paper itself

Abstract

Due to the properties of silver as an antimicrobial, our research group has synthesized many different silver carbene complexes. Two new silver N-heterocyclic carbene complexes derived from 4,5-dichloroimidazole and theobromine bearing methyl benzoate substituents were synthesized by in situ carbene formation using silver acetate as the base in the reaction. The new compounds were fully characterized by several methods including NMR spectroscopy and X-ray crystallography. Preliminary antimicrobial efficacy studies against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli were conducted. The results of this study demonstrated antimicrobial efficacy of the two complexes comparable to silver nitrate, showing their potential for use in the treatment of bacterial infections.

Identifiers

PMID21218156
PMCPMC3014616
OpenAlexW2001315412

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.