Evidence map›Paper›PMID 21218090›Full record

Trial reportWorld journal of gastroenterology2011

Effect of ginger on gastric motility and symptoms of functional dyspepsia.

Ming-Luen Hu, Christophan K Rayner, Keng-Liang Wu, Seng-Kee Chuah, Wei-Chen Tai, Yeh-Pin Chou, Yi-Chun Chiu, King-Wah Chiu, Tsung-Hui Hu

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 4 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02809027 phase4completednot on this mapstarted 2016, after this paper: background citation

A Randomized Double-blind Placebo-controlled Trial on the Efficacy of Ginger in the Prevention of Abdominal Distention in Post Cesarean Section Patient

TypeinterventionalSponsorChulalongkorn UniversityRan2016 to 2017Enrolled178ConditionsPost Cesarean Section PatientArmsGinger, Placebo
NCT04153552 nacompletednot on this mapstarted 2019, after this paper: background citation

Evaluation of the Impact of the HLNatural, Inc. Upset Stomach Relief Product on the Reduction of Symptoms in Adults Who Suffer From Mild to Moderate Indigestion and Heartburn

TypeinterventionalSponsorHawthorne Effect Inc.Ran2019 to 2020Enrolled161ConditionsIndigestion, HeartburnArmsHLNatural, Inc. Upset Stomach Relief
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Pooled it
  2. Non-Chinese herbal medicines for functional dyspepsia.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Gongronema latifolium delays gastric emptying of semi-solid meals in diabetic dogs.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2013
    Trial
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. [Functional Dyspepsia].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
    Review
  17. Article
  18. Review
  19. Nutraceuticals and biotics in pediatric gastrointestinal disorders.European journal of clinical nutrition · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ming-Luen HuMing-Luen Hu, Keng-Liang Wu, Seng-Kee Chuah, Wei-Chen Tai, Yeh-Pin Chou, Yi-Chun Chiu, King-Wah Chiu, Tsung-Hui Hu, Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Christophan K Rayner
Keng-Liang Wu
Seng-Kee Chuah
Wei-Chen Tai
Yeh-Pin Chou
Yi-Chun Chiu
King-Wah Chiu
Tsung-Hui Hu
Chang Gung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia.

methodsEleven patients with functional dyspepsia were studied twice in a randomized double-blind manner. After an 8-h fast, the patients ingested three capsules that contained ginger (total 1.2 g) or placebo, followed after 1 h by 500 mL low-nutrient soup. Antral area, fundus area and diameter, and the frequency of antral contractions were measured using ultrasound at frequent intervals, and the gastric half-emptying time was calculated from the change in antral area. Gastrointestinal sensations and appetite were scored using visual analog questionnaires, and blood was taken for measurement of plasma glucagon-like peptide-1 (GLP-1), motilin and ghrelin concentrations, at intervals throughout the study.

resultsGastric emptying was more rapid after ginger than placebo [median (range) half-emptying time 12.3 (8.5-17.0) min after ginger, 16.1 (8.3-22.6) min after placebo, P≤0.05]. There was a trend for more antral contractions (P=0.06), but fundus dimensions and gastrointestinal symptoms did not differ, nor did serum concentrations of GLP-1, motilin and ghrelin.

conclusionGinger stimulated gastric emptying and antral contractions in patients with functional dyspepsia, but had no impact on gastrointestinal symptoms or gut peptides.

Indexed as

Double-Blind MethodDyspepsiaGastric EmptyingGastrointestinal MotilityGhrelinGlucagon-Like Peptide 1HumansMotilinPain MeasurementPlacebosPlant ExtractsStomachZingiber officinaleGhrelinGlucagon-Like Peptide 1MotilinPlacebosPlant ExtractsAbdominal ultrasoundAntral contractionFunctional dyspepsiaGastric emptyingGhrelinGinger (Zinger offinale)Glucagon-like peptide-1Motilin

Identifiers

PMID21218090
PMCPMC3016669
OpenAlexW2125916968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.