ArticleKorean journal of pediatrics2010
Pathogenesis and clinical manifestations of juvenile rheumatoid arthritis.
Article in Korean journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Low-energy laser therapy application on knee joints as an auxiliary treatment in patients with polyarticular juvenile idiopathic arthritis: a dual-arm randomized clinical trial.Lasers in medical science · 2022Trial
- A narrative review of multidisciplinary rehabilitation in juvenile idiopathic arthritis.Clinical rheumatology · 2025Review
- Article
- Safety and efficacy of biologic immunosuppressive treatment in juvenile idiopathic arthritis associated with inborn errors of immunity.Frontiers in pediatrics · 2024Article
- Pericardial effusion in children admitted with juvenile idiopathic arthritis: A multicenter retrospective cohort study from the pediatric health information system.Archives of rheumatology · 2023Article
- Article
- Integrative Analysis of Transcriptome-Wide Association Study and Gene-Based Association Analysis Identifies In Silico Candidate Genes Associated with Juvenile Idiopathic Arthritis.International journal of molecular sciences · 2022Article
- Serine, N-acetylaspartate differentiate adolescents with juvenile idiopathic arthritis compared with healthy controls: a metabolomics cross-sectional study.Pediatric rheumatology online journal · 2022Article
- Juvenile Idiopathic Arthritis: A Review of Novel Diagnostic and Monitoring Technologies.Healthcare (Basel, Switzerland) · 2021Review
- Best practices for recruitment of adolescents for biobanking and precision health research: a retrospective analysis comparing juvenile idiopathic arthritis cases with healthy controls.Pediatric rheumatology online journal · 2021Article
- Left to themselves: Time to target chronic pain in childhood rare diseases.Neuroscience and biobehavioral reviews · 2021Review
- Utilizing ultrasound findings of a single indicator joint to assess non-systemic juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2021Article
- A new biopsychosocial and clinical questionnaire to assess juvenile idiopathic arthritis: JAB-Q.Rheumatology international · 2018Article
- Patients with juvenile idiopathic arthritis in clinical remission with positive power Doppler signal in joint ultrasonography have an increased rate of clinical flare: a prospective study.Pediatric rheumatology online journal · 2017Article
- Comparisons of the outcomes between early and late tocilizumab treatment in systemic juvenile idiopathic arthritis.Rheumatology international · 2017Observational
- The role of sex in uveitis and ocular inflammation.International ophthalmology clinics · 2015Review
- Do patients with juvenile idiopathic arthritis in remission exhibit active synovitis on joint ultrasound?Rheumatology international · 2014Article
- Association of juvenile idiopathic arthritis and digeorge syndrome; a case report.Iranian journal of pediatrics · 2014Article
- Importance of adherence in the outcome of juvenile idiopathic arthritis.Current rheumatology reports · 2014Review
- The role of gender in juvenile idiopathic arthritis-associated uveitis.Journal of ophthalmology · 2014Review
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Juvenile rheumatoid arthritis (JRA) is the most common rheumatic childhood disease; its onset is before 16 years of age and it persists for at least 6 weeks. JRA encompasses a heterogeneous group of diseases that is classified according to 3 major presentations: oligoarthritis, polyarthritis, and systemic onset diseases. These presentations may originate from the same or different causes that involve interaction with specific immunogenetic predispositions, and result in heterogeneous clinical manifestations. An arthritic joint exhibits cardinal signs of joint inflammation, such as swelling, pain, heat, and loss of function; any joint can be arthritic, but large joints are more frequently affected. Extra-articular manifestations include high fever, skin rash, serositis, and uveitis. The first 2 types of JRA are regarded as T helper 1 (Th1) cell-mediated inflammatory disorders, mainly based on the abundance of activated Th1 cells in the inflamed synovium and the pathogenetic role of proinflammatory cytokines that are mainly produced by Th1 cell-stimulated monocytes. In contrast, the pathogenesis of systemic onset disease differs from that of other types of JRA in several respects, including the lack of association with human leukocyte antigen type and the absence of autoantibodies or autoreactive T cells. Although the precise mechanism that leads to JRA remains unclear, proinflammatory cytokines are thought to be responsible for at least part of the clinical symptoms in all JRA types. The effectiveness of biologic therapy in blocking the action of these cytokines in JRA patients provides strong evidence that they play a fundamental role in JRA inflammation.
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