ArticleInterdisciplinary toxicology2010
Different experimental approaches in modelling cataractogenesis: An overview of selenite-induced nuclear cataract in rats.
Article in Interdisciplinary toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Toxicoproteomic analysis reveals arsenic-induced alterations in eye lens proteins of Labeo rohita.Fish physiology and biochemistry · 2026Article
- Investigation of protective effect of carvacrol in an experimental cataract model.International ophthalmology · 2025Article
- Minimizing Oxidative Stress in the Lens: Alternative Measures for Elevating Glutathione in the Lens to Protect against Cataract.Antioxidants (Basel, Switzerland) · 2024Review
- The Aqueous Stem Bark Extract ofScientifica · 2023Article
- Anticataract Effect of the Aqueous Extract of the Flowers ofAdvances in pharmacological and pharmaceutical sciences · 2023Article
- Natural Antioxidant Activities of Plants in Preventing Cataractogenesis.Antioxidants (Basel, Switzerland) · 2022Review
- Current Trends in the Pharmacotherapy of Cataracts.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- The Claim of Anti-Cataract Potential of Heliotropium indicum: A Myth or Reality?Ophthalmology and therapy · 2015Article
- Protein misfolding and aggregation in cataract disease and prospects for prevention.Trends in molecular medicine · 2012Review
- Ursodeoxycholic acid prevents selenite-induced oxidative stress and alleviates cataract formation: In vitro and in vivo studies.Molecular vision · 2012Article
- Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract.Interdisciplinary toxicology · 2011Article
- Selenium and mercury in the Brazilian Amazon: opposing influences on age-related cataracts.Environmental health perspectives · 2010Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cataract, the opacification of eye lens, is the leading cause of blindness worldwide. At present, the only remedy is surgical removal of the cataractous lens and substitution with a lens made of synthetic polymers. However, besides significant costs of operation and possible complications, an artificial lens just does not have the overall optical qualities of a normal one. Hence it remains a significant public health problem, and biochemical solutions or pharmacological interventions that will maintain the transparency of the lens are highly required. Naturally, there is a persistent demand for suitable biological models. The ocular lens would appear to be an ideal organ for maintaining culture conditions because of lacking blood vessels and nerves. The lens in vivo obtains its nutrients and eliminates waste products via diffusion with the surrounding fluids. Lens opacification observed in vivo can be mimicked in vitro by addition of the cataractogenic agent sodium selenite (Na(2)SeO(3)) to the culture medium. Moreover, since an overdose of sodium selenite induces also cataract in young rats, it became an extremely rapid and convenient model of nuclear cataract in vivo. The main focus of this review will be on selenium (Se) and its salt sodium selenite, their toxicological characteristics and safety data in relevance of modelling cataractogenesis, either under in vivo or in vitro conditions. The studies revealing the mechanisms of lens opacification induced by selenite are highlighted, the representatives from screening for potential anti-cataract agents are listed.
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