ArticleNature neuroscience2011
Biophysical mechanisms underlying olfactory receptor neuron dynamics.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
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Who cites it
130 citing papers in PubMed, 234 citations in OpenAlex.
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- Molecular evolution of CO2-sensing ab1C neurons underlies divergent sensory responses in the Drosophila suzukii species group.PLoS genetics · 2026Article
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- A hardwired neural circuit for temporal difference learning.bioRxiv : the preprint server for biology · 2025Article
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- Nonlinear high-activity neuronal excitation enhances odor discrimination.Current biology : CB · 2025Article
- A Spike Train Production Mechanism Based on Intermittency Dynamics.Entropy (Basel, Switzerland) · 2025Article
- A vector-based strategy for olfactory navigation inbioRxiv : the preprint server for biology · 2025Article
- Serotonin acts through multiple cellular targets during an olfactory critical period.iScience · 2024Article
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- Stimulus duration encoding occurs early in the moth olfactory pathway.Communications biology · 2024Article
- Odour source distance is predictable from a time history of odour statistics for large scale outdoor plumes.Journal of the Royal Society, Interface · 2024Article
- Response Plasticity ofInternational journal of molecular sciences · 2024Article
70 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The responses of olfactory receptor neurons (ORNs) to odors have complex dynamics. Using genetics and pharmacology, we found that these dynamics in Drosophila ORNs could be separated into sequential steps, corresponding to transduction and spike generation. Each of these steps contributed distinct dynamics. Transduction dynamics could be largely explained by a simple kinetic model of ligand-receptor interactions, together with an adaptive feedback mechanism that slows transduction onset. Spiking dynamics were well described by a differentiating linear filter that was stereotyped across odors and cells. Genetic knock-down of sodium channels reshaped this filter, implying that it arises from the regulated balance of intrinsic conductances in ORNs. Complex responses can be understood as a consequence of how the stereotyped spike filter interacts with odor- and receptor-specific transduction dynamics. However, in the presence of rapidly fluctuating natural stimuli, spiking simply increases the speed and sensitivity of encoding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.